All Phenotypes Tnfaip3<tm1Ama> MGI Mouse

Phenotypes associated with this allele

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Tnfaip3^tm1Ama/Tnfaip3^tm1Ama	involves: C57BL/6J	MGI:3055280
hm2	Tnfaip3^tm1Ama/Tnfaip3^tm1Ama	Not Specified	MGI:3056505
cx3	Tnf^tm1Gkl/Tnf^tm1Gkl Tnfaip3^tm1Ama/Tnfaip3^tm1Ama	involves: 129S/SvEv * C57BL/6J	MGI:3055288
cx4	Tnfaip3^tm1Ama/Tnfaip3^tm1Ama Tnfrsf1a^tm1Imx/Tnfrsf1a^tm1Imx	involves: C57BL/6J	MGI:3055284
cx5	Tnfaip3^tm1Ama/Tnfaip3^tm1Ama Tnfrsf1a^tm1Imx/Tnfrsf1a⁺	involves: C57BL/6J	MGI:3055286

Allelic Composition	Tnfaip3^tm1Ama/Tnfaip3^tm1Ama
Genetic Background	involves: C57BL/6J

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tnfaip3^tm1Ama mutation (0 available); any Tnfaip3 mutation (43 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

abnormal cytokine secretion ( J:92694 )

• bone marrow derived macrophages produce more TNF, IL-6, and nitric oxide in response to LPS treatment compared to wild-type macrophages

abnormal inflammatory response ( J:92694 )

• the absolute number and percentage of myeloid cells is increased in multiple tissues

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

increased susceptibility to induced morbidity/mortality ( J:92931 )

• increased sensitivity to LPS and TNF induced-lethality are seen

premature death ( J:92931 )

postnatal lethality, incomplete penetrance ( J:92931 )

• homozygotes begin to die after 1 week of age

digestive/alimentary system

intestinal inflammation ( J:92931 )

• severe inflammation and tissue damage are seen at 3 to 6 weeks of age

growth/size/body

decreased body size ( J:92931 )

• homozygotes are runted by 1 week of age

hematopoietic system

increased granulocyte number ( J:92931 )

• increased numbers of activated granulocytes are seen in spleens and livers

increased lymphocyte cell number ( J:92931 )

• increased numbers of activated lymphocytes are seen in spleens and livers

increased macrophage cell number ( J:92931 )

• increased numbers of activated granulocytes are seen in spleens and livers

immune system

increased granulocyte number ( J:92931 )

• increased numbers of activated granulocytes are seen in spleens and livers

increased lymphocyte cell number ( J:92931 )

• increased numbers of activated lymphocytes are seen in spleens and livers

increased macrophage cell number ( J:92931 )

• increased numbers of activated granulocytes are seen in spleens and livers

increased inflammatory response ( J:92931 )

• severe bone marrow inflammation and tissue damage are seen at 3 to 6 weeks of age

intestinal inflammation ( J:92931 )

• severe inflammation and tissue damage are seen at 3 to 6 weeks of age

joint inflammation ( J:92931 )

• severe inflammation and tissue damage are seen at 3 to 6 weeks of age

liver inflammation ( J:92931 )

• severe inflammation and tissue damage are seen at 3 to 6 weeks of age

kidney inflammation ( J:92931 )

• severe inflammation and tissue damage are seen at 3 to 6 weeks of age

renal/urinary system

kidney inflammation ( J:92931 )

• severe inflammation and tissue damage are seen at 3 to 6 weeks of age

skeleton

joint inflammation ( J:92931 )

• severe inflammation and tissue damage are seen at 3 to 6 weeks of age

liver/biliary system

liver inflammation ( J:92931 )

• severe inflammation and tissue damage are seen at 3 to 6 weeks of age

integument

thick dermal layer ( J:92931 )

thick epidermis ( J:92931 )

Allelic Composition	Tnf^tm1Gkl/Tnf^tm1Gkl Tnfaip3^tm1Ama/Tnfaip3^tm1Ama
Genetic Background	involves: 129S/SvEv * C57BL/6J

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tnfaip3^tm1Ama mutation (0 available); any Tnfaip3 mutation (43 available)
Tnf^tm1Gkl mutation (6 available); any Tnf mutation (46 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

premature death ( J:92694 )

growth/size/body

cachexia ( J:92694 )

immune system

abnormal cytokine secretion ( J:92694 )

• bone marrow derived macrophages produce more IL-6 and nitric oxide in response to LPS treatment compared to Tnfaip1^tm1Ama heterozygous Tnf^tm1Gkl homozygous macrophages

abnormal inflammatory response ( J:92694 )

• the absolute number and percentage of myeloid cells is increased in multiple tissues

Allelic Composition	Tnfaip3^tm1Ama/Tnfaip3^tm1Ama Tnfrsf1a^tm1Imx/Tnfrsf1a^tm1Imx
Genetic Background	involves: C57BL/6J

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tnfaip3^tm1Ama mutation (0 available); any Tnfaip3 mutation (43 available)
Tnfrsf1a^tm1Imx mutation (6 available); any Tnfrsf1a mutation (47 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

premature death ( J:92694 )

growth/size/body

decreased body size ( J:92694 )

cachexia ( J:92694 )

immune system

abnormal inflammatory response ( J:92694 )

• the absolute number and percentage of myeloid cells is increased in multiple tissues

Allelic Composition	Tnfaip3^tm1Ama/Tnfaip3^tm1Ama Tnfrsf1a^tm1Imx/Tnfrsf1a⁺
Genetic Background	involves: C57BL/6J

Find Mice

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

premature death ( J:92694 )

growth/size/body

decreased body size ( J:92694 )

cachexia ( J:92694 )

immune system

abnormal inflammatory response ( J:92694 )

• the absolute number and percentage of myeloid cells is increased in multiple tissues

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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