Phenotypes associated with this allele

• Allele Symbol: Ptpn13^tm1Wjh
• Allele Name: targeted mutation 1, Wiljan Hendriks
• Allele ID: MGI:3054733
• Summary: 3 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Ptpn13^tm1Wjh/Ptpn13^tm1Wjh	B6.129P2-Ptpn13^tm1Wjh	MGI:3852524
hm2	Ptpn13^tm1Wjh/Ptpn13^tm1Wjh	involves: 129P2/OlaHsd * C57BL/6	MGI:3054741
cx3	Ptpn13^tm1Wjh/Ptpn13^tm1Wjh Ptpn3^tm1Pdk/Ptpn3^tm1Pdk Ptpn4^Gt(OST146128)Lex/Ptpn4^Gt(OST146128)Lex	involves: 129P2/OlaHsd * 129S5/SvEvBrd * C57BL/6	MGI:3831001

Genotype
MGI:3852524

hm1

• Allelic Composition: Ptpn13^tm1Wjh/Ptpn13^tm1Wjh
• Genetic Background: B6.129P2-Ptpn13^tm1Wjh

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

nervous system

abnormal glial cell morphology ( J:101070 )

• there are less mean GFAP⁺ glia in three-day cultures using cells from mice with lens injuries compared to controls

abnormal retina ganglion cell morphology ( J:101070 )

• a smaller percentage of retinal ganglion cells cultured from injuried eyes have neurites compared to controls

vision/eye

abnormal retina ganglion cell morphology ( J:101070 )

• a smaller percentage of retinal ganglion cells cultured from injuried eyes have neurites compared to controls

cellular

abnormal glial cell morphology ( J:101070 )

• there are less mean GFAP⁺ glia in three-day cultures using cells from mice with lens injuries compared to controls

Genotype
MGI:3054741

hm2

• Allelic Composition: Ptpn13^tm1Wjh/Ptpn13^tm1Wjh
• Genetic Background: involves: 129P2/OlaHsd * C57BL/6

growth/size/body

obese ( J:92590 )

• males in early generations developed a mild obese phenotype

• weight difference was first noticeable at 4 months of age

• males were significantly heavier at 15 months of age

• phenotype was mostly due to white adipose tissue

• phenotype disappeared by the F9 generation

nervous system

abnormal innervation ( J:92590 )

• motor nerve recovery from a sciatic nerve crush lesion was slowed, taking up to 5 weeks as opposed to 3 weeks in controls

• sensory nerve recovery was normal however

abnormal axon morphology ( J:92590 )

• diminished axonal branching observed during the course of recovery from sciatic nerve crush lesion

hematopoietic system

increased T-helper 2 cell number ( J:144351 )

• mice exhibit increased differentiation into T-helper 2 cells compared to in wild-type mice

• however, differentiation into other T-helper cells is normal

immune system

increased T-helper 2 cell number ( J:144351 )

• mice exhibit increased differentiation into T-helper 2 cells compared to in wild-type mice

• however, differentiation into other T-helper cells is normal

Genotype
MGI:3831001

cx3

• Allelic Composition: Ptpn13^tm1Wjh/Ptpn13^tm1Wjh; Ptpn3^tm1Pdk/Ptpn3^tm1Pdk; Ptpn4^{Gt(OST146128)Lex}/Ptpn4^{Gt(OST146128)Lex}
• Genetic Background: involves: 129P2/OlaHsd * 129S5/SvEvBrd * C57BL/6

immune system

immune system phenotype ( J:144351 )

N • mice exhibit normal immune compartment and T-helper cell differentiation