Ptpn3^tm1Pdk
Targeted Allele Detail

Summary

• Symbol: Ptpn3^tm1Pdk
• Name: protein tyrosine phosphatase, non-receptor type 3; targeted mutation 1, Phillip D King
• MGI ID: MGI:3830864
• Gene: Ptpn3 Location: Chr4:57190841-57301837 bp, - strand Genetic Position: Chr4, 31.66 cM
• Alliance: Ptpn3^tm1Pdk page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:144280
• Parent Cell Line: Bruce 4 (ES Cell)
• Strain of Origin: B6.Cg-Thy1^a

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Insertion
• Mutation details: A loxP-site was inserted upstream of exon 27 in a Hind-III restriction enzyme site, and a loxP site and a Frt-flanked neomycin cassette was inserted downstream of exon 27 at another Hind-III restriction site. The presence of the neomycin resistance cassette generated a null allele as determined by failure to detect full length protein in immunoblot analysis of homozygote brain extracts. (J:144280)

Expression

In Mice Carrying this Mutation:

7 assay results

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Ptpn3 Mutation: 173 strains or lines available

References

• Original: J:144280 Bauler TJ, et al., Normal TCR signal transduction in mice that lack catalytically active PTPN3 protein tyrosine phosphatase. J Immunol. 2007 Mar 15;178(6):3680-7
• All: 2 reference(s)