Phenotypes associated with this allele

• Allele Symbol: Tg(HBV)10Imeg
• Allele Name: transgene insertion 10, Institute of Molecular Embryology and Genetics
• Allele ID: MGI:3054659
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
tg1	Tg(HBV)10Imeg/0	involves: C57BL/6	MGI:6278184

Genotype
MGI:6278184

tg1

• Allelic Composition: Tg(HBV)10Imeg/0
• Genetic Background: involves: C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

immune system

abnormal dendritic cell physiology ( J:95283 )

• liver dendritic cells are inefficient at inducing proliferation of both allogenic T lymphocytes and hepatitis B surface antigen (HBsAg)-enriched T lymphocytes, indicating that dendritic cells are impaired in inducing both innate and adaptive immune responses

abnormal cytokine secretion ( J:95283 )

• mice exhibit decreased levels of cytokines interleukin-12p70, tumor necrosis factor-alpha, interferon-gamma, and interleukin-10 in the supernatants of allogenic mixed lymphocyte reaction cultures containing liver dendritic cells

• liver dendritic cells produce decreased level of proinflammatory cytokines (TNF-alpha, IFN-gamma, IL-6 and IL-12p70) when stimulated with viral and bacterial products

liver/biliary system

liver/biliary system phenotype ( J:95283 )

N • mice do not develop hepatitis and instead model carriers of hepatitis B virus