All Phenotypes Tg(Pcp2-cre)3555Jdhu MGI Mouse

About Help FAQ

Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Tg(Pcp2-cre)3555Jdhu
transgene insertion 3555, Jian-Dong Huang
MGI:3053828

Summary

2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
cn1	Gt(ROSA)26Sor^tm1Sor/Gt(ROSA)26Sor⁺ Pdss2^tm1.1Jdhu/Pdss2^tm1.2Jdhu Tg(Pcp2-cre)3555Jdhu/0	involves: 129 * C3H/HeNCr MMTV^- * C57BL/6N * FVB/N	MGI:5304570
cn2	Ndufs4^tm1Rpa/Ndufs4^tm1Rpa Tg(Pcp2-cre)3555Jdhu/0	involves: 129S4/SvJaeSor * C3H/HeNCrMtv^- * C57BL/6NCr	MGI:4818646

Allelic Composition	Gt(ROSA)26Sor^tm1Sor/Gt(ROSA)26Sor⁺ Pdss2^tm1.1Jdhu/Pdss2^tm1.2Jdhu Tg(Pcp2-cre)3555Jdhu/0
Genetic Background	involves: 129 * C3H/HeNCr MMTV^- * C57BL/6N * FVB/N

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gt(ROSA)26Sor^tm1Sor mutation (8 available); any Gt(ROSA)26Sor mutation (944 available)
Pdss2^tm1.1Jdhu mutation (0 available); any Pdss2 mutation (31 available)
Pdss2^tm1.2Jdhu mutation (0 available); any Pdss2 mutation (31 available)
Tg(Pcp2-cre)3555Jdhu mutation (1 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

behavior/neurological

abnormal motor coordination/balance ( J:179845 )

• at 9.5 months, mice exhibit failure in motor coordination during walking and incapability to maintain balance on a rod

ataxia ( J:179845 )

• gradual

impaired balance ( J:179845 )

abnormal gait ( J:179845 )

• mice exhibit shorter and more variable strides with more frequent additional steps made by both forepaw and hindpaw compared with wild-type mice

short stride length ( J:179845 )

• and more variable

nervous system

increased neuron apoptosis ( J:179845 )

• at 6 months in the cerebellum

Purkinje cell degeneration ( J:179845 )

• in the cerebellum of aged mice

decreased Purkinje cell number ( J:179845 )

• at 6 months in the cerebellum

cellular

increased neuron apoptosis ( J:179845 )

• at 6 months in the cerebellum

Allelic Composition	Ndufs4^tm1Rpa/Ndufs4^tm1Rpa Tg(Pcp2-cre)3555Jdhu/0
Genetic Background	involves: 129S4/SvJaeSor * C3H/HeNCrMtv^- * C57BL/6NCr

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ndufs4^tm1Rpa mutation (1 available); any Ndufs4 mutation (27 available)
Tg(Pcp2-cre)3555Jdhu mutation (1 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

behavior/neurological

behavior/neurological phenotype ( J:161393 )

N	• mice do not exhibit any overt behavioral abnormalities

nervous system

nervous system phenotype ( J:161393 )

N	• mice do not exhibit any overt pathology

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 05/07/2024 MGI 6.23