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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Scarf1tm1Ishi
targeted mutation 1, Shun Ishibashi
MGI:3052974
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Scarf1tm1Ishi/Scarf1tm1Ishi involves: 129S7/SvEvBrd * C57BL/6J MGI:3053050
cx2
 		Msr1tm1Csk/Msr1tm1Csk
Scarf1tm1Ishi/Scarf1tm1Ishi 		involves: 129S7/SvEvBrd * 129X1/SvJ * C57BL/6J MGI:3053051


Genotype
MGI:3053050
hm1
Allelic
Composition		 Scarf1tm1Ishi/Scarf1tm1Ishi
Genetic
Background		 involves: 129S7/SvEvBrd * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Scarf1tm1Ishi mutation (0 available); any Scarf1 mutation (38 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
normal phenotype
no abnormal phenotype detected ( J:91911 )
• homozygotes are viable and fertile with no abnormalities detected in plasma glucose, cholesterol, or triglycerides, or in the brain, lung, heart, kidney, liver, or testes




Genotype
MGI:3053051
cx2
Allelic
Composition		 Msr1tm1Csk/Msr1tm1Csk
Scarf1tm1Ishi/Scarf1tm1Ishi
Genetic
Background		 involves: 129S7/SvEvBrd * 129X1/SvJ * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Msr1tm1Csk mutation (4 available); any Msr1 mutation (10 available)
Scarf1tm1Ishi mutation (0 available); any Scarf1 mutation (38 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
abnormal macrophage physiology ( J:91911 )
• macrophage uptake and degradation of acetylated low density lipoproteins involved in the development of atherosclerosis
• this reduction is slightly greater than that of Msr1tm1Kod homozygotes

hematopoietic system
abnormal macrophage physiology ( J:91911 )
• macrophage uptake and degradation of acetylated low density lipoproteins involved in the development of atherosclerosis
• this reduction is slightly greater than that of Msr1tm1Kod homozygotes




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
04/23/2024
MGI 6.23 		The Jackson Laboratory