Scarf1^tm1Ishi
Targeted Allele Detail

Summary

• Symbol: Scarf1^tm1Ishi
• Name: scavenger receptor class F, member 1; targeted mutation 1, Shun Ishibashi
• MGI ID: MGI:3052974
• Synonyms: SREC-1^-
• Gene: Scarf1 Location: Chr11:75404366-75417408 bp, + strand Genetic Position: Chr11, 45.92 cM
• Alliance: Scarf1^tm1Ishi page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:91911
• Parent Cell Line: JH1 (ES Cell)
• Strain of Origin: 129S7/SvEvBrd

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A targeting vector was constructed to replace a 35 bp segment in exon 8, which encodes two thirds of the transmembrane domain, with a neomycin resistance gene. Northern blot of paritoneal macrophages indicated that mutants expressed a truncated transcript lacking the transmembrane domain. (J:91911)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Scarf1 Mutation: 40 strains or lines available

References

• Original: J:91911 Tamura Y, et al., Scavenger receptor expressed by endothelial cells I (SREC-I) mediates the uptake of acetylated low density lipoproteins by macrophages stimulated with lipopolysaccharide. J Biol Chem. 2004 Jul 23;279(30):30938-44
• All: 1 reference(s)