Phenotypes associated with this allele

• Allele Symbol: Sall3^tm1Apm
• Allele Name: targeted mutation 1, A P Monaghan
• Allele ID: MGI:3052730
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Sall3^tm1Apm/Sall3^tm1Apm	involves: 129X1/SvJ	MGI:3053431

Genotype
MGI:3053431

hm1

• Allelic Composition: Sall3^tm1Apm/Sall3^tm1Apm
• Genetic Background: involves: 129X1/SvJ

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

neonatal lethality, complete penetrance ( J:92241 )

• homozygotes are born alive but die within 12 hours

• death can be delayed with intraperitoneal injections of 20% sucrose-PBS every 2 hours

behavior/neurological

abnormal suckling behavior ( J:92241 )

• mutants are unable to suckle normally

impaired righting response ( J:92241 )

• around 27% of mutants do not display a righting reflex at birth

weakness ( J:92241 )

• over 50% of mutants have an impaired ability to support their weight compared to wild-type littermates

craniofacial

abnormal soft palate morphology ( J:92241 )

• the ventral extension of the soft palate is reduced or absent resulting in an enlarged nasopharyngeal opening

abnormal tongue morphology ( J:92241 )

• in mutants the anterior portion of the tongue is about 8% wider than normal at birth

homeostasis/metabolism

dehydration ( J:92241 )

• inability to suckle results in dehydration

respiratory system

abnormal epiglottis morphology ( J:92241 )

• the epiglottis is smaller than normal with a sagging or wilted appearance

• combined with the soft palate abnormality this results in an inability to close off the trachea during suckling

skeleton

abnormal epiglottis morphology ( J:92241 )

• the epiglottis is smaller than normal with a sagging or wilted appearance

• combined with the soft palate abnormality this results in an inability to close off the trachea during suckling

nervous system

abnormal cranial nerve morphology ( J:92241 )

• the percent of mutants with fusions of or connections between the proximal glossopharyngeal nerve and the vagal or spinal accessory nerves was doubled compared to wild-type littermates

• in 8% of mutants the inferior glossopharyngeal nerve is not connected to the hindbrain

abnormal hypoglossal nerve morphology ( J:92241 )

• more mutants display truncations of the most posterior roots that contribute to the hypoglossal nerve compared to wild-type littermates

abnormal somatic sensory system morphology ( J:92241 )

• more mutants have persistent dorsal root-like ganglia at the anterior cervical level compared to wild-type littermates

digestive/alimentary system

abnormal soft palate morphology ( J:92241 )

• the ventral extension of the soft palate is reduced or absent resulting in an enlarged nasopharyngeal opening

abnormal tongue morphology ( J:92241 )

• in mutants the anterior portion of the tongue is about 8% wider than normal at birth

abnormal epiglottis morphology ( J:92241 )

• the epiglottis is smaller than normal with a sagging or wilted appearance

• combined with the soft palate abnormality this results in an inability to close off the trachea during suckling

growth/size/body

abnormal soft palate morphology ( J:92241 )

• the ventral extension of the soft palate is reduced or absent resulting in an enlarged nasopharyngeal opening

abnormal tongue morphology ( J:92241 )

• in mutants the anterior portion of the tongue is about 8% wider than normal at birth