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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Hhat+
wild type
MGI:3052539
Summary 3 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
ht1
 		Hhatem1(IMPC)Ccpcz/Hhat+ C57BL/6NCrl-Hhatem1(IMPC)Ccpcz/Ccpcz MGI:7768350
cx2
 		HhatTg(TFAP2A-cre)1Will/Hhat+
Shhtm1Chg/Shh+ 		involves: 129S1/Sv * 129X1/SvJ MGI:5447986
cx3
 		HhatTg(TFAP2A-cre)1Will/Hhat+
Ptch1tm1Mps/Ptch1+ 		involves: 129S1/Sv * 129X1/SvJ MGI:5447987


Genotype
MGI:7768350
ht1
Allelic
Composition		 Hhatem1(IMPC)Ccpcz/Hhat+
Genetic
Background		 C57BL/6NCrl-Hhatem1(IMPC)Ccpcz/Ccpcz
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Hhatem1(IMPC)Ccpcz mutation (1 available); any Hhat mutation (27 available)
Data Sources
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
endocrine/exocrine glands
enlarged thymus ( J:211773 )
IMPC - CCP-IMG

growth/size/body
enlarged spleen ( J:211773 )
IMPC - CCP-IMG

hematopoietic system
enlarged thymus ( J:211773 )
IMPC - CCP-IMG
enlarged spleen ( J:211773 )
IMPC - CCP-IMG

immune system
enlarged thymus ( J:211773 )
IMPC - CCP-IMG
enlarged spleen ( J:211773 )
IMPC - CCP-IMG




Genotype
MGI:5447986
cx2
Allelic
Composition		 HhatTg(TFAP2A-cre)1Will/Hhat+
Shhtm1Chg/Shh+
Genetic
Background		 involves: 129S1/Sv * 129X1/SvJ
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
HhatTg(TFAP2A-cre)1Will mutation (1 available); any Hhat mutation (27 available)
Shhtm1Chg mutation (2 available); any Shh mutation (48 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
craniofacial
abnormal craniofacial morphology ( J:190013 )
• E17.5-18.5 embryos have craniofacial defects that are not consistent with holoprosencephaly showing that the transgene did not insert into Shh.




Genotype
MGI:5447987
cx3
Allelic
Composition		 HhatTg(TFAP2A-cre)1Will/Hhat+
Ptch1tm1Mps/Ptch1+
Genetic
Background		 involves: 129S1/Sv * 129X1/SvJ
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
HhatTg(TFAP2A-cre)1Will mutation (1 available); any Hhat mutation (27 available)
Ptch1tm1Mps mutation (2 available); any Ptch1 mutation (113 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
craniofacial
abnormal craniofacial morphology ( J:190013 )
• E17.5-18.5 embryos have craniofacial defects that are not consistent with holoprosencephaly showing that the transgene did not insert into Ptch1.




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
03/25/2025
MGI 6.24 		The Jackson Laboratory