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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Ciitatm2Wrth
targeted mutation 2, Walter Reith
MGI:3052223
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Ciitatm2Wrth/Ciitatm2Wrth B6.129P2-Ciitatm2Wrth MGI:3696681
hm2
 		Ciitatm2Wrth/Ciitatm2Wrth involves: 129P2/OlaHsd * C57BL/6 MGI:3052466


Genotype
MGI:3696681
hm1
Allelic
Composition		 Ciitatm2Wrth/Ciitatm2Wrth
Genetic
Background		 B6.129P2-Ciitatm2Wrth
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ciitatm2Wrth mutation (0 available); any Ciita mutation (49 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
immune system phenotype ( J:117111 )
N
• mice do not show decreased levels of soluble MHC-II, suggesting that B cells, dendritic cells and stromal cells do not contribute significantly to circulating levels of soluble I-Ab




Genotype
MGI:3052466
hm2
Allelic
Composition		 Ciitatm2Wrth/Ciitatm2Wrth
Genetic
Background		 involves: 129P2/OlaHsd * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ciitatm2Wrth mutation (0 available); any Ciita mutation (49 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
hematopoietic system
decreased CD4-positive, alpha-beta T cell number ( J:92170 )
• reduced numbers of CD4+ T cells
• results in lymphopenia
abnormal immunoglobulin level ( J:92170 )
• no antibody response to T-cell dependent antigens

immune system
decreased CD4-positive, alpha-beta T cell number ( J:92170 )
• reduced numbers of CD4+ T cells
• results in lymphopenia
abnormal immunoglobulin level ( J:92170 )
• no antibody response to T-cell dependent antigens

Mouse Models of Human Disease
 DO ID OMIM ID(s) Ref(s)
MHC class II deficiency DOID:5812 OMIM:209920
 J:92170




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
09/30/2025
MGI 6.24 		The Jackson Laboratory