Phenotypes associated with this allele

• Allele Symbol: Tg(Myog-Ntf3)5160Wds
• Allele Name: transgene insertion 5160, William D Snider
• Allele ID: MGI:3052131
• Summary: 3 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
cx1	Ntrk1^tm2(Ntrk3)Apat/Ntrk1^tm2(Ntrk3)Apat Tg(Myog-Ntf3)5160Wds/0	involves: 129S1/Sv	MGI:3052169
cx2	Ntf3^tm1Jae/Ntf3^tm1Jae Tg(Myog-Ntf3)5160Wds/0	involves: C57BL/6 * CBA * CF-1	MGI:3052162
tg3	Tg(Myog-Ntf3)5160Wds/0	involves: C57BL/6 * CBA * CF-1	MGI:3052160

Genotype
MGI:3052169

cx1

• Allelic Composition: Ntrk1^{tm2(Ntrk3)Apat}/Ntrk1^{tm2(Ntrk3)Apat}; Tg(Myog-Ntf3)5160Wds/0
• Genetic Background: involves: 129S1/Sv

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

nervous system

abnormal proprioceptive neuron morphology ( J:92099 )

• a synergistic increase in the number of proprioceptive neurons is seen compared to either allele alone including a 7 fold or 11 fold increase in soleus muscle spindles compared to either Tg(Myog-Ntf3)5160Wds transgenic or wild-type mice respectively

Genotype
MGI:3052162

cx2

• Allelic Composition: Ntf3^tm1Jae/Ntf3^tm1Jae; Tg(Myog-Ntf3)5160Wds/0
• Genetic Background: involves: C57BL/6 * CBA * CF-1

mortality/aging

postnatal lethality, complete penetrance ( J:43444 )

• mutants die soon after birth presumably from cardiac defects similar to Ntf3^tm1Jae homozygotes

nervous system

abnormal muscle spindle morphology ( J:43444 )

• abnormal clusters of spindle bundles are seen

abnormal dorsal root ganglion morphology ( J:43444 )

• a 54% decrease compared to wild-type in the overall number of dorsal root ganglia neurons at L4 is seen in newborn mice this represents a partial recovery from the 63% deficiency seen in Ntf3^tm1Jae homozygotes

abnormal proprioceptive neuron morphology ( J:43444 )

• the number of proprioceptive neurons and spindle bundles are decreased in most skeletal muscles however this decrease is not as great as in Ntf3^tm1Jae homozygotes

• this rescue is muscle specific with no recovery in the soleus muscles and almost complete recovery in the medial gastrocnemius

muscle

abnormal muscle spindle morphology ( J:43444 )

• abnormal clusters of spindle bundles are seen

Genotype
MGI:3052160

tg3

• Allelic Composition: Tg(Myog-Ntf3)5160Wds/0
• Genetic Background: involves: C57BL/6 * CBA * CF-1

nervous system

abnormal muscle spindle morphology ( J:43444 )

• abnormal clusters of spindle bundles are seen

abnormal dorsal root ganglion morphology ( J:43444 )

• a slight but significant increase in the overall number of dorsal root ganglia neurons at L4 is seen in 4 - 5 week old mice

• a 24% increase in the number of myelinated axons compared to wild-type littermates is seen

abnormal proprioceptive neuron morphology ( J:43444 )

• the number of proprioceptive neurons and spindle bundles are increased in most skeletal muscles except the soleus and external hallucis longus muscles

muscle

abnormal muscle spindle morphology ( J:43444 )

• abnormal clusters of spindle bundles are seen