Phenotypes associated with this allele

• Allele Symbol: Pik3cg^tm1Ehi
• Allele Name: targeted mutation 1, Emilio Hirsch
• Allele ID: MGI:3051886
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Pik3cg^tm1Ehi/Pik3cg^tm1Ehi	Not Specified	MGI:3051977

Genotype
MGI:3051977

hm1

• Allelic Composition: Pik3cg^tm1Ehi/Pik3cg^tm1Ehi
• Genetic Background: Not Specified

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

cardiovascular system

abnormal myocardial fiber morphology ( J:91945 )

• in response to transverse aortic constriction, cardiomyocytes are reduced in size, possibly as a result of a reduction in sustained Akt1 phosphorylation

abnormal heart ventricle morphology ( J:91945 )

• in response to transverse aortic constriction, mutants exhibit a reduced left ventricular response as evidenced by decreased left ventricular wall thickening

immune system

impaired macrophage chemotaxis ( J:91945 )

• in response to induced peritonitis, macrophage recruitment is reduced. Kinase activity is required for G protein-coupled receptor mediated Akt1 activation and chemotactic response

impaired neutrophil recruitment ( J:91945 )

• in response to induced peritonitis, neutrophil recruitment is reduced

hematopoietic system

impaired macrophage chemotaxis ( J:91945 )

• in response to induced peritonitis, macrophage recruitment is reduced. Kinase activity is required for G protein-coupled receptor mediated Akt1 activation and chemotactic response

impaired neutrophil recruitment ( J:91945 )

• in response to induced peritonitis, neutrophil recruitment is reduced

decreased platelet aggregation ( J:152267 )

• adenosine 5'-diphosphate (ADP)-induced platelet aggregation is impaired unlike in similarly treated wild-type cells

• when treated with U46619, platelet aggregation is impaired 30% compared to in similarly treated wild-type cells

• convulxin-induced aggregation is slightly reduced compared to in similarly treated wild-type cells

• however, platelet adhesion and spreading are normal

muscle

abnormal myocardial fiber morphology ( J:91945 )

• in response to transverse aortic constriction, cardiomyocytes are reduced in size, possibly as a result of a reduction in sustained Akt1 phosphorylation

homeostasis/metabolism

decreased platelet aggregation ( J:152267 )

• adenosine 5'-diphosphate (ADP)-induced platelet aggregation is impaired unlike in similarly treated wild-type cells

• when treated with U46619, platelet aggregation is impaired 30% compared to in similarly treated wild-type cells

• convulxin-induced aggregation is slightly reduced compared to in similarly treated wild-type cells

• however, platelet adhesion and spreading are normal

cellular

impaired macrophage chemotaxis ( J:91945 )

• in response to induced peritonitis, macrophage recruitment is reduced. Kinase activity is required for G protein-coupled receptor mediated Akt1 activation and chemotactic response