All Phenotypes Alpl<Hpp> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Alpl^Hpp
hypophosphatasia
MGI:3051587

Summary

2 genotypes

Allelic Composition	Alpl^Hpp/Alpl^Hpp
Genetic Background	involves: BALB/cAnN * C3H/HeH

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Alpl^Hpp mutation (2 available); any Alpl mutation (351 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

homeostasis/metabolism

• plasma ALP levels are very low, but detectable in 5 week old homozygotes

• ALP levels decrease further with age at a similar rate to controls

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
adult hypophosphatasia		DOID:0110913	OMIM:146300	J:122319

Allelic Composition	Alpl^Hpp/Alpl⁺
Genetic Background	involves: BALB/cAnN * C3H/HeH

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Alpl^Hpp mutation (2 available); any Alpl mutation (351 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

homeostasis/metabolism

• plasma ALP levels are less than 50% of controls at 5 weeks of age (J:122319)

• ALP levels decrease further with age at a similar rate to controls (J:122319)

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
adult hypophosphatasia		DOID:0110913	OMIM:146300	J:122319

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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