Phenotypes associated with this allele
Allelic
Composition |
Or8a1tm26Mom/Or8a1+
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Genetic
Background |
involves: 129P2/OlaHsd * C57BL/6 |
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Or8a1tm26Mom mutation
(3 available);
any
Or8a1 mutation
(69 available)
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nervous system
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• glomeruli in heterozygotes containing the C57BL/6 pseudogene are reduced from ~50 um diameter to ~32 um in diameter
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• there is ~50% reduction of axonal inputs innervating glomeruli; all axons are of Olfr151
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nervous system
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• Hyb C axons co-converge and co-mingle with Olfr151-GFP axons in the glomeruli
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nervous system
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• atypical glomeruli are formed in which some co-mingling of Olfr151tm2Momaxons with both Olfr151 and Olfr160 axons occurs, but Olfr151tm2Momaxons are shared between glomeruli
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nervous system
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• Hyb A axons co-converge and co-mingle with Olfr151-GFP axons in the glomeruli
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nervous system
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• olfactory sensory neuron axons form ectopic, ventral glomeruli in the olfactory bulb either with or without the presence of glomeruli in the expected position
• when only ectopic glomeruli are present both red and green axons are present; however when two pairs of glomeruli are present the ectopic glomeruli contain primarily red axons
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Allelic
Composition |
Ebf2tm1Reed/Ebf2+
Or8a1tm26Mom/Or8a1+
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Genetic
Background |
involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ |
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ebf2tm1Reed mutation
(0 available);
any
Ebf2 mutation
(30 available)
Or8a1tm26Mom mutation
(3 available);
any
Or8a1 mutation
(69 available)
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nervous system
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• most olfactory receptor neurons project to multiple more ventral glomeruli
• P2 olfactory receptor neurons extend much shorter axons and project into the ventral region of the bulb
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craniofacial
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• most olfactory receptor neurons project to multiple more ventral glomeruli
• P2 olfactory receptor neurons extend much shorter axons and project into the ventral region of the bulb
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respiratory system
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• most olfactory receptor neurons project to multiple more ventral glomeruli
• P2 olfactory receptor neurons extend much shorter axons and project into the ventral region of the bulb
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taste/olfaction
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• most olfactory receptor neurons project to multiple more ventral glomeruli
• P2 olfactory receptor neurons extend much shorter axons and project into the ventral region of the bulb
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growth/size/body
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• most olfactory receptor neurons project to multiple more ventral glomeruli
• P2 olfactory receptor neurons extend much shorter axons and project into the ventral region of the bulb
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Analysis Tools