Analysis Tools
muscle
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• heterozygotes are viable and fertile, grow to adulthood with no overt developmental or behavioral phenotypes up to 1 year of age, and show normal skeletal and cardiac muscle histology with no evidence of skeletal muscle fibrosis
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• following cardiotoxin-induced injury of the tibialis anterior muscles, heterozygotes display a modest delay in the removal of necrotic tissue and slower growth at the midpoint of the regenerative process relative to wild-type controls
• however, skeletal muscle regeneration ultimately occurs and no overt muscular dystrophy phenotype is observed
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