Phenotypes associated with this allele
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Hprt1tm1Dhm mutation
(0 available);
any
Hprt1 mutation
(1274 available)
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cardiovascular system
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• the ratio of left ventricular weight to both tibia length and body weight is increased at 10 weeks of age
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• exhibit mild hypertrophy
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• isolated cardiac myocytes exhibit a significant decrease in fractional cell shortening and smaller dL/dT values
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• the first derivatives of minimum and maximum left ventricular pressure, the fractional shortening, velocity of circumferential shortening corrected, and peak early-filling transmitral diastolic wave velocity are all decreased
• treatment with isoproternol, a beta-adrenergic activator, reversed cardiac impairment in mutant hearts
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• isolated cardiac myocytes exhibit lower relaxation rates (-dL/dt) than wild-type
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• under baseline conditions, left ventricular myocytes exhibit lower calcium transient amplitude and slower calcium transient decays
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muscle
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• isolated cardiac myocytes exhibit a significant decrease in fractional cell shortening and smaller dL/dT values
|
|
|
• the first derivatives of minimum and maximum left ventricular pressure, the fractional shortening, velocity of circumferential shortening corrected, and peak early-filling transmitral diastolic wave velocity are all decreased
• treatment with isoproternol, a beta-adrenergic activator, reversed cardiac impairment in mutant hearts
|
|
|
• isolated cardiac myocytes exhibit lower relaxation rates (-dL/dt) than wild-type
|
growth/size/body
|
|
• the ratio of left ventricular weight to both tibia length and body weight is increased at 10 weeks of age
|
|
|
• exhibit mild hypertrophy
|
|
|
| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Hprt1tm1Dhm mutation
(0 available);
any
Hprt1 mutation
(1274 available)
Plntm1Egk mutation
(7 available);
any
Pln mutation
(16 available)
|
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cardiovascular system
|
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• isolated cardiac myocytes exhibit enhanced fractional cell shortening and higher dL/dT values compared to wild-type, however this shortening and dL/dT values are less than that seen in the single homozygous Pln mutant mouse
|
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• isolated cardiac myocytes exhibit higher relaxation rates (-dL/dt) than wild-type but lower than that seen in single homozygous Pln mutant mice
|
|
|
• under baseline conditions, left ventricular myocytes exhibit faster calcium transient decays than wild-type, however they are slower than in single homozygous Pln mutant mice
|
muscle
|
|
• isolated cardiac myocytes exhibit enhanced fractional cell shortening and higher dL/dT values compared to wild-type, however this shortening and dL/dT values are less than that seen in the single homozygous Pln mutant mouse
|
|
|
• isolated cardiac myocytes exhibit higher relaxation rates (-dL/dt) than wild-type but lower than that seen in single homozygous Pln mutant mice
|
|
|
| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Hprt1tm1Dhm mutation
(0 available);
any
Hprt1 mutation
(1274 available)
Plntm1Egk mutation
(7 available);
any
Pln mutation
(16 available)
|
|
|
cardiovascular system
 |
• isolated cardiac myocytes exhibit enhanced fractional cell shortening and higher dL/dT values compared to wild-type, however this shortening and dL/dT values are less than that seen in the single homozygous Pln mutant mouse
|
|
|
• isolated cardiac myocytes exhibit higher relaxation rates (-dL/dt) than wild-type but lower than that seen in single homozygous Pln mutant mice
|
|
|
• under baseline conditions, left ventricular myocytes exhibit faster calcium transient decays than wild-type, however they are slower than in single homozygous Pln mutant mice
|
muscle
|
|
• isolated cardiac myocytes exhibit enhanced fractional cell shortening and higher dL/dT values compared to wild-type, however this shortening and dL/dT values are less than that seen in the single homozygous Pln mutant mouse
|
|
|
• isolated cardiac myocytes exhibit higher relaxation rates (-dL/dt) than wild-type but lower than that seen in single homozygous Pln mutant mice
|
Allelic
Composition |
Hprt1tm1Dhm/Y
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Genetic
Background |
involves: 129P2/OlaHsd |
|
| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Hprt1tm1Dhm mutation
(0 available);
any
Hprt1 mutation
(1274 available)
|
|
|
cardiovascular system
|
|
• the ratio of left ventricular weight to both tibia length and body weight is increased at 10 weeks of age
|
|
|
• exhibit mild hypertrophy
|
|
|
• isolated cardiac myocytes exhibit a significant decrease in fractional cell shortening and smaller dL/dT values
|
|
|
• the first derivatives of minimum and maximum left ventricular pressure, the fractional shortening, velocity of circumferential shortening corrected, and peak early-filling transmitral diastolic wave velocity are all decreased
• treatment with isoproternol, a beta-adrenergic activator, reversed cardiac impairment in mutant hearts
|
|
|
• isolated cardiac myocytes exhibit lower relaxation rates (-dL/dt) than wild-type
|
|
|
• under baseline conditions, left ventricular myocytes exhibit lower calcium transient amplitude and slower calcium transient decays
|
muscle
|
|
• isolated cardiac myocytes exhibit a significant decrease in fractional cell shortening and smaller dL/dT values
|
|
|
• the first derivatives of minimum and maximum left ventricular pressure, the fractional shortening, velocity of circumferential shortening corrected, and peak early-filling transmitral diastolic wave velocity are all decreased
• treatment with isoproternol, a beta-adrenergic activator, reversed cardiac impairment in mutant hearts
|
|
|
• isolated cardiac myocytes exhibit lower relaxation rates (-dL/dt) than wild-type
|
growth/size/body
|
|
• the ratio of left ventricular weight to both tibia length and body weight is increased at 10 weeks of age
|
|
|
• exhibit mild hypertrophy
|
Analysis Tools