Hprt1^tm1Dhm
Targeted Allele Detail

Summary

• Symbol: Hprt1^tm1Dhm
• Name: hypoxanthine phosphoribosyltransferase 1; targeted mutation 1, David H MacLennan
• MGI ID: MGI:3050087
• Synonyms: NF-SLN
• Gene: Hprt1 Location: ChrX:52077014-52110536 bp, + strand Genetic Position: ChrX, 29.31 cM, cytoband A6
• Alliance: Hprt1^tm1Dhm page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:91410
• Parent Cell Line: BK4 (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Inserted expressed sequence)
• Mutation: Insertion
• Mutation details: A construct containing part of the Hprt promoter, the alpha-myosin heavy-chain promoter, rabbit NF-SLN cDNA, pA, and Hprt sequence containing exons 1-3 was inserted into ES cells lacking Hprt promoter and exons 1 and 2. Successful recombination was confirmed by PCR. (J:91410)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Hprt1 Mutation: 1273 strains or lines available

References

• Original: J:91410 Asahi M, et al., Cardiac-specific overexpression of sarcolipin inhibits sarco(endo)plasmic reticulum Ca2+ ATPase (SERCA2a) activity and impairs cardiac function in mice. Proc Natl Acad Sci U S A. 2004 Jun 22;101(25):9199-204
• All: 2 reference(s)