All Phenotypes Trp53bp2<+> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Trp53bp2⁺
wild type
MGI:3049973

Summary

8 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
ht1	Trp53bp2^tm1Xlu/Trp53bp2⁺	B6.129S6-Trp53bp2^tm1Xlu	MGI:6191759
ht2	Trp53bp2^tm1Xlu/Trp53bp2⁺	C.129S6-Trp53bp2^tm1Xlu	MGI:6191760
ht3	Trp53bp2^{tm1b(EUCOMM)Hmgu}/Trp53bp2⁺	C57BL/6N-Trp53bp2^{tm1b(EUCOMM)Hmgu}/H	MGI:6679323
ht4	Trp53bp2^tm1Cdlo/Trp53bp2⁺	involves: 129S1/Sv * 129X1/SvJ * C57BL/6	MGI:3839866
ht5	Trp53bp2^tm1Xlu/Trp53bp2⁺	involves: 129S6/SvEvTac * C57BL/6J	MGI:3629204
cx6	Trp53^tm1Brd/Trp53⁺ Trp53bp2^tm1Cdlo/Trp53bp2⁺	involves: 129S1/Sv * 129S7/SvEvBrd * 129X1/SvJ * C57BL/6	MGI:3839867
cx7	Trp53bp2^tm1Cdlo/Trp53bp2⁺ Tg(EmuSR-tTa)83Bop/0 Tg(tetO-MYC)36aBop/0	involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * FVB/N	MGI:3839868
cx8	Trp53^tm1Tyj/Trp53⁺ Trp53bp2^tm1Xlu/Trp53bp2⁺	involves: 129S2/SvPas * 129S6/SvEvTac * C57BL/6J	MGI:3629207

Allelic Composition	Trp53bp2^tm1Xlu/Trp53bp2⁺
Genetic Background	B6.129S6-Trp53bp2^tm1Xlu

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Trp53bp2^tm1Xlu mutation (0 available); any Trp53bp2 mutation (52 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

cardiovascular system

ventricular septal defect ( J:240594 )

• 30% incidence of ventricular septal defect

craniofacial

cleft palate ( J:240594 )

• 30% incidence of cleft palate

digestive/alimentary system

cleft palate ( J:240594 )

• 30% incidence of cleft palate

growth/size/body

cleft palate ( J:240594 )

• 30% incidence of cleft palate

nervous system

abnormal spinal cord central canal morphology ( J:240594 )

• 20% incidence of spinal canal abnormalities

vision/eye

abnormal retina morphology ( J:240594 )

• 30% incidence of retinal abnormalities

Allelic Composition	Trp53bp2^tm1Xlu/Trp53bp2⁺
Genetic Background	C.129S6-Trp53bp2^tm1Xlu

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Trp53bp2^tm1Xlu mutation (0 available); any Trp53bp2 mutation (52 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

cardiovascular system

ventricular septal defect ( J:240594 )

• 13% incidence of ventricular septal defect

hemorrhage ( J:240594 )

• small patches of subcranial hemorrhage

embryo

abnormal embryonic neuroepithelium morphology ( J:240594 )

• 25% of embryos show localized abnormalities in the distribution of neuroepithelial brain tissue associated with small patches of subcranial hemorrhage

nervous system

abnormal embryonic neuroepithelium morphology ( J:240594 )

• 25% of embryos show localized abnormalities in the distribution of neuroepithelial brain tissue associated with small patches of subcranial hemorrhage

abnormal lateral ventricle morphology ( J:240594 )

• 25% incidence of asymmetric lateral ventricles

Allelic Composition	Trp53bp2^{tm1b(EUCOMM)Hmgu}/Trp53bp2⁺
Genetic Background	C57BL/6N-Trp53bp2^{tm1b(EUCOMM)Hmgu}/H
Cell Lines	HEPD0778_8_A12

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Trp53bp2^{tm1b(EUCOMM)Hmgu} mutation (1 available); any Trp53bp2 mutation (52 available)

Data Sources

IMPC Data for Trp53bp2

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

behavior/neurological

hyperactivity ( J:211773 )

IMPC - HAR

hematopoietic system

increased hemoglobin content ( J:211773 )

IMPC - HAR

homeostasis/metabolism

increased circulating aspartate transaminase level ( J:211773 )

IMPC - HAR

Allelic Composition	Trp53bp2^tm1Cdlo/Trp53bp2⁺
Genetic Background	involves: 129S1/Sv * 129X1/SvJ * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Trp53bp2^tm1Cdlo mutation (0 available); any Trp53bp2 mutation (52 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

neoplasm

increased tumor incidence ( J:146764 )

• increased tumor incidence but the spectrum of tumor types is similar to controls

increased incidence of tumors by ionizing radiation induction ( J:146764 )

• unlike wild-type controls, mice develop tumors following exposure to 6.0 Gy or 10.5 Gy of gamma-radiation

• induced tumors are high grade lymphomas

immune system

abnormal T cell physiology ( J:146764 )

• attenuated T cell apoptotic response following gamma-irradiation

cellular

abnormal cell cycle checkpoint function ( J:146764 )

• attenuated G0/G1 checkpoint function following gamma-irradiation

hematopoietic system

abnormal T cell physiology ( J:146764 )

• attenuated T cell apoptotic response following gamma-irradiation

Allelic Composition	Trp53bp2^tm1Xlu/Trp53bp2⁺
Genetic Background	involves: 129S6/SvEvTac * C57BL/6J

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Trp53bp2^tm1Xlu mutation (0 available); any Trp53bp2 mutation (52 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

neoplasm

increased tumor incidence ( J:108701 )

• incidence of tumors (12/20) is much higher in heterozygous mice than in wild-type mice (4/18) over a 3 year period

increased rhabdomyosarcoma incidence ( J:108701 )

• 1/20 spontaneously developed this sarcoma: only observed in irradiated heterozygous mice, not in wild-type

increased lymphoma incidence ( J:108701 )

• 40% of mice develop lymphomas; in wild-type this is the only type of tumor occurring tumor origin is determined to be T and B cell-derived

increased T cell derived lymphoma incidence ( J:108701 )

• T cell lymphomas in various tissues are observed in both irradiated heterozygous and wild-type mice

increased squamous cell carcinoma incidence ( J:108701 )

• 1/20 showed squamous cell carcinoma

increased hemangiosarcoma incidence ( J:108701 )

• 2/20 heterozygotes developed angiosarcoma

increased incidence of tumors by ionizing radiation induction ( J:108701 )

• more irradiated heterozygotes (9/19) develop tumors than untreated heterozygotes (1/19) or irradiated wild-type mice (3/19)

muscle

increased rhabdomyosarcoma incidence ( J:108701 )

• 1/20 spontaneously developed this sarcoma: only observed in irradiated heterozygous mice, not in wild-type

endocrine/exocrine glands

increased T cell derived lymphoma incidence ( J:108701 )

• T cell lymphomas in various tissues are observed in both irradiated heterozygous and wild-type mice

hematopoietic system

increased T cell derived lymphoma incidence ( J:108701 )

• T cell lymphomas in various tissues are observed in both irradiated heterozygous and wild-type mice

immune system

increased T cell derived lymphoma incidence ( J:108701 )

• T cell lymphomas in various tissues are observed in both irradiated heterozygous and wild-type mice

Allelic Composition	Trp53^tm1Brd/Trp53⁺ Trp53bp2^tm1Cdlo/Trp53bp2⁺
Genetic Background	involves: 129S1/Sv * 129S7/SvEvBrd * 129X1/SvJ * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Trp53bp2^tm1Cdlo mutation (0 available); any Trp53bp2 mutation (52 available)
Trp53^tm1Brd mutation (5 available); any Trp53 mutation (249 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

neoplasm

increased tumor incidence ( J:146764 )

• increased tumor incidence compared to wild-type controls but not compared to mice heterozygous for the Trp53 allele alone

Allelic Composition	Trp53bp2^tm1Cdlo/Trp53bp2⁺ Tg(EmuSR-tTa)83Bop/0 Tg(tetO-MYC)36aBop/0
Genetic Background	involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * FVB/N

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tg(EmuSR-tTa)83Bop mutation (1 available)
Tg(tetO-MYC)36aBop mutation (1 available)
Trp53bp2^tm1Cdlo mutation (0 available); any Trp53bp2 mutation (52 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

neoplasm

increased T cell derived lymphoma incidence ( J:146764 )

• incidence of T cell lymphomas is similar to that in transgenic mice wild-type for Trp53bp2

endocrine/exocrine glands

increased T cell derived lymphoma incidence ( J:146764 )

• incidence of T cell lymphomas is similar to that in transgenic mice wild-type for Trp53bp2

hematopoietic system

increased T cell derived lymphoma incidence ( J:146764 )

• incidence of T cell lymphomas is similar to that in transgenic mice wild-type for Trp53bp2

immune system

increased T cell derived lymphoma incidence ( J:146764 )

• incidence of T cell lymphomas is similar to that in transgenic mice wild-type for Trp53bp2

Allelic Composition	Trp53^tm1Tyj/Trp53⁺ Trp53bp2^tm1Xlu/Trp53bp2⁺
Genetic Background	involves: 129S2/SvPas * 129S6/SvEvTac * C57BL/6J

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Trp53bp2^tm1Xlu mutation (0 available); any Trp53bp2 mutation (52 available)
Trp53^tm1Tyj mutation (12 available); any Trp53 mutation (249 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

neoplasm

increased tumor incidence ( J:108701 )

• 26% of double heterozygotes develop tumors over a 72 week period

increased lymphoma incidence ( J:108701 )

• lymphoma development is accelerated in compared to Trp53 heterozygotes with wild-type Trp53bp2; at 42 weeks there is a significant difference in the onset between the two genotypes

• at 72 weeks the difference in onset of lymphoma development is not significant

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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