All Phenotypes Trib2<+> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Trib2⁺
wild type
MGI:3049959

Summary

2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
ht1	Trib2^{tm1b(KOMP)Wtsi}/Trib2⁺	C57BL/6N-Trib2^{tm1b(KOMP)Wtsi}/Bay	MGI:6288797
cx2	Trib2^{Tg(Thy1-Trh/APP)2.1Ingm}/Trib2⁺ Tg(Thy1-APP)2.2Ingm/0	involves: C57BL/6 * DBA/1	MGI:5294359

Allelic Composition	Trib2^{tm1b(KOMP)Wtsi}/Trib2⁺
Genetic Background	C57BL/6N-Trib2^{tm1b(KOMP)Wtsi}/Bay
Cell Lines	EPD0096_1_C01

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Trib2^{tm1b(KOMP)Wtsi} mutation (0 available); any Trib2 mutation (30 available)

Data Sources

IMPC Data for Trib2

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

homeostasis/metabolism

decreased circulating cholesterol level ( J:211773 )

IMPC - BCM

vision/eye

abnormal retina inner nuclear layer morphology ( J:211773 )

IMPC - BCM

decreased total retina thickness ( J:211773 )

IMPC - BCM

Allelic Composition	Trib2^{Tg(Thy1-Trh/APP)2.1Ingm}/Trib2⁺ Tg(Thy1-APP)2.2Ingm/0
Genetic Background	involves: C57BL/6 * DBA/1

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tg(Thy1-APP*)2.2Ingm mutation (0 available)
Trib2^{Tg(Thy1-Trh/APP*)2.1Ingm} mutation (0 available); any Trib2 mutation (30 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

nervous system

astrocytosis ( J:176575 )

• onset is later than in mice homozygous for Trib2^{Tg(Thy1-Trh/APP*)2.1Ingm}

microgliosis ( J:176575 )

• onset is later than in mice homozygous for Trib2^{Tg(Thy1-Trh/APP*)2.1Ingm}

hippocampus pyramidal cell degeneration ( J:176575 )

• neurodegeneration in the CA1 pyramidal cell layer

• onset is later than in mice homozygous for Trib2^{Tg(Thy1-Trh/APP*)2.1Ingm}

behavior/neurological

impaired righting response ( J:176575 )

• delayed

• onset is later than in mice homozygous for Trib2^{Tg(Thy1-Trh/APP*)2.1Ingm}

limb grasping ( J:176575 )

• display cramping or tremors when lifted by the tail

• onset is later than in mice homozygous for Trib2^{Tg(Thy1-Trh/APP*)2.1Ingm}

growth/size/body

decreased body weight ( J:176575 )

slow postnatal weight gain ( J:176575 )

• onset is later than in mice homozygous for Trib2^{Tg(Thy1-Trh/APP*)2.1Ingm}

hematopoietic system

microgliosis ( J:176575 )

• onset is later than in mice homozygous for Trib2^{Tg(Thy1-Trh/APP*)2.1Ingm}

immune system

microgliosis ( J:176575 )

• onset is later than in mice homozygous for Trib2^{Tg(Thy1-Trh/APP*)2.1Ingm}

cellular

astrocytosis ( J:176575 )

• onset is later than in mice homozygous for Trib2^{Tg(Thy1-Trh/APP*)2.1Ingm}

microgliosis ( J:176575 )

• onset is later than in mice homozygous for Trib2^{Tg(Thy1-Trh/APP*)2.1Ingm}

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
Alzheimer's disease		DOID:10652		J:176575

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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