About   Help   FAQ
Transgenic Allele Detail
Symbol: Trib2Tg(Thy1-Trh/APP*)2.1Ingm
Name: tribbles pseudokinase 2; transgene insertion 2.1, Ingenium Pharmaceuticals
MGI ID: MGI:5294354
Synonyms: TBA2.1
Gene: Trib2  Location: Chr12:15841728-15866923 bp, - strand  Genetic Position: Chr12, 7.25 cM
Alliance: Trib2Tg(Thy1-Trh/APP*)2.1Ingm page
Strain of Origin:  Not Specified
Transgene Type:    Transgenic (Inserted expressed sequence)
Mutations:    Insertion, Intragenic deletion
Trib2Tg(Thy1-Trh/APP*)2.1Ingm expresses 1 gene
Mutation detailsThe Thy1 regulatory sequence directs expression of a fusion protein of the pre-pro-peptide of murine thyrotropin releasing hormone and the N terminus of the modified human amyloid beta polypeptide, Abeta(Q3?42). This transgene expresses an N terminally truncated A beta protein that is glutamate to glutamine modified at position 3 and engineered to liberate its product preferentially within the secretory pathway. Multiple copies of the transgene inserted into position 15.5-16.5 Mbp (based on NCBI Build 36 ) on chromosome 12 resulting in deletion of Trib2. Maximal transgene expression was seen between P12 and P28. (J:176575)
View phenotypes and curated references for all genotypes (concatenated display).
Disease models
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Trib2 Mutation:  28 strains or lines available
Original:  J:176575 Alexandru A, et al., Selective Hippocampal Neurodegeneration in Transgenic Mice Expressing Small Amounts of Truncated A{beta} Is Induced by Pyroglutamate-A{beta} Formation. J Neurosci. 2011 Sep 7;31(36):12790-12801
All:  6 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support.
last database update
MGI 6.13
The Jackson Laboratory