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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Tmprss6+
wild type
MGI:3049927
Summary 4 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
ht1
 		Tmprss6tm1Dgen/Tmprss6+ B6.129P2-Tmprss6tm1Dgen/Crl MGI:4457132
ht2
 		Tmprss6tm1Dgen/Tmprss6+ involves: 129P2/OlaHsd * 129S4/SvJae * 129S6/SvEvTac * C57BL/6 MGI:4457138
cx3
 		Hjvtm1Nca/Hjvtm1Nca
Tmprss6tm1Dgen/Tmprss6+ 		involves: 129P2/OlaHsd * 129S4/SvJae * 129S6/SvEvTac * C57BL/6 MGI:4457135
cx4
 		Hbb-b1tm1Unc/Hbb-b1+
Hbb-b2tm1Unc/Hbb-b2+
Tmprss6tm1Otin/Tmprss6+ 		involves: 129P2/OlaHsd * C57BL/6 * C57BL/6N MGI:5441342


Genotype
MGI:4457132
ht1
Allelic
Composition		 Tmprss6tm1Dgen/Tmprss6+
Genetic
Background		 B6.129P2-Tmprss6tm1Dgen/Crl
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tmprss6tm1Dgen mutation (0 available); any Tmprss6 mutation (44 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
hematopoietic system
decreased spleen iron level ( J:160248 )
• slightly in pregnant mice compared with pregnant wild-type mice

homeostasis/metabolism
decreased spleen iron level ( J:160248 )
• slightly in pregnant mice compared with pregnant wild-type mice
decreased circulating iron level ( J:160248 )
• mice exhibit a trend toward decreased serum iron levels compared with wild-type mice
decreased liver iron level ( J:160248 )
• mice exhibit decreased hepatic iron levels compared with wild-type mice

liver/biliary system
decreased liver iron level ( J:160248 )
• mice exhibit decreased hepatic iron levels compared with wild-type mice

immune system
decreased spleen iron level ( J:160248 )
• slightly in pregnant mice compared with pregnant wild-type mice

cellular
maternal effect ( J:160248 )
• pup from heterozygous dams exhibit reduced hepatic iron levels compared with pups from wild-type mice
• however, pups from heterozygous dams exhibit normal hematologic and serum parameters




Genotype
MGI:4457138
ht2
Allelic
Composition		 Tmprss6tm1Dgen/Tmprss6+
Genetic
Background		 involves: 129P2/OlaHsd * 129S4/SvJae * 129S6/SvEvTac * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tmprss6tm1Dgen mutation (0 available); any Tmprss6 mutation (44 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
hematopoietic system




Genotype
MGI:4457135
cx3
Allelic
Composition		 Hjvtm1Nca/Hjvtm1Nca
Tmprss6tm1Dgen/Tmprss6+
Genetic
Background		 involves: 129P2/OlaHsd * 129S4/SvJae * 129S6/SvEvTac * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Hjvtm1Nca mutation (1 available); any Hjv mutation (19 available)
Tmprss6tm1Dgen mutation (0 available); any Tmprss6 mutation (44 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
homeostasis/metabolism
abnormal iron level ( J:160248 )
• at 8 weeks, mice exhibit increased liver, heart, pancreas, and muscle iron levels compared with wild-type mice
decreased spleen iron level ( J:160248 )
• spleen iron levels are decreased compared to in wild-type mice
• splenic macrophages exhibit decreased iron levels compared with wild-type cells
increased liver iron level ( J:160248 )
• at 8 weeks, specifically in hepatocytes

hematopoietic system
abnormal macrophage morphology ( J:160248 )
• splenic macrophages exhibit decreased iron levels compared with wild-type cells
decreased spleen iron level ( J:160248 )
• spleen iron levels are decreased compared to in wild-type mice
• splenic macrophages exhibit decreased iron levels compared with wild-type cells

liver/biliary system
increased liver iron level ( J:160248 )
• at 8 weeks, specifically in hepatocytes
abnormal hepatocyte morphology ( J:160248 )
• hepatocytes exhibit increased iron accumulation compared with wild-type cells

immune system
abnormal macrophage morphology ( J:160248 )
• splenic macrophages exhibit decreased iron levels compared with wild-type cells
decreased spleen iron level ( J:160248 )
• spleen iron levels are decreased compared to in wild-type mice
• splenic macrophages exhibit decreased iron levels compared with wild-type cells




Genotype
MGI:5441342
cx4
Allelic
Composition		 Hbb-b1tm1Unc/Hbb-b1+
Hbb-b2tm1Unc/Hbb-b2+
Tmprss6tm1Otin/Tmprss6+
Genetic
Background		 involves: 129P2/OlaHsd * C57BL/6 * C57BL/6N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Hbb-b1tm1Unc mutation (2 available); any Hbb-b1 mutation (7 available)
Hbb-b2tm1Unc mutation (2 available); any Hbb-b2 mutation (5 available)
Tmprss6tm1Otin mutation (0 available); any Tmprss6 mutation (44 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
hematopoietic system
abnormal erythrocyte cell number ( J:185154 )
• increased in males and females compared to mutant male and female mice wild-type for Tmprss6 at 6 months of age
abnormal hemoglobin content ( J:185154 )
• increased in males compared to mutant male mice wild-type for Tmprss6
decreased mean corpuscular volume ( J:185154 )
• decreased in males compared to mutant male mice wild-type for Tmprss6 at 6 months of age
abnormal spleen iron level ( J:185154 )
• total spleen iron, but not iron per gram of tissue, is decreased in males compared to mutant male mice wild-type for Tmprss6
abnormal spleen size ( J:185154 )
• reduced size in males compared to mutant male mice wild-type for Tmprss6

homeostasis/metabolism
abnormal spleen iron level ( J:185154 )
• total spleen iron, but not iron per gram of tissue, is decreased in males compared to mutant male mice wild-type for Tmprss6
abnormal circulating erythropoietin level ( J:185154 )
• decreased in males compared to mutant male mice wild-type for Tmprss6
abnormal liver iron level ( J:185154 )
• decreased in males compared to mutant male mice wild-type for Tmprss6

liver/biliary system
abnormal liver iron level ( J:185154 )
• decreased in males compared to mutant male mice wild-type for Tmprss6

immune system
abnormal spleen iron level ( J:185154 )
• total spleen iron, but not iron per gram of tissue, is decreased in males compared to mutant male mice wild-type for Tmprss6
abnormal spleen size ( J:185154 )
• reduced size in males compared to mutant male mice wild-type for Tmprss6




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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
03/18/2025
MGI 6.24 		The Jackson Laboratory