About   Help   FAQ
Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Tmprss6+
wild type
MGI:3049927
Summary 4 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
ht1
 		Tmprss6tm1Dgen/Tmprss6+ B6.129P2-Tmprss6tm1Dgen/Crl MGI:4457132
ht2
 		Tmprss6tm1Dgen/Tmprss6+ involves: 129P2/OlaHsd * 129S4/SvJae * 129S6/SvEvTac * C57BL/6 MGI:4457138
cx3
 		Hjvtm1Nca/Hjvtm1Nca
Tmprss6tm1Dgen/Tmprss6+ 		involves: 129P2/OlaHsd * 129S4/SvJae * 129S6/SvEvTac * C57BL/6 MGI:4457135
cx4
 		Hbb-b1tm1Unc/Hbb-b1+
Hbb-b2tm1Unc/Hbb-b2+
Tmprss6tm1Otin/Tmprss6+ 		involves: 129P2/OlaHsd * C57BL/6 * C57BL/6N MGI:5441342


Genotype
MGI:4457132
ht1
Allelic
Composition		 Tmprss6tm1Dgen/Tmprss6+
Genetic
Background		 B6.129P2-Tmprss6tm1Dgen/Crl
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tmprss6tm1Dgen mutation (0 available); any Tmprss6 mutation (45 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
hematopoietic system
decreased spleen iron level ( J:160248 )
• slightly in pregnant mice compared with pregnant wild-type mice

homeostasis/metabolism
decreased spleen iron level ( J:160248 )
• slightly in pregnant mice compared with pregnant wild-type mice
decreased circulating iron level ( J:160248 )
• mice exhibit a trend toward decreased serum iron levels compared with wild-type mice
decreased liver iron level ( J:160248 )
• mice exhibit decreased hepatic iron levels compared with wild-type mice

liver/biliary system
decreased liver iron level ( J:160248 )
• mice exhibit decreased hepatic iron levels compared with wild-type mice

immune system
decreased spleen iron level ( J:160248 )
• slightly in pregnant mice compared with pregnant wild-type mice

cellular
maternal effect ( J:160248 )
• pup from heterozygous dams exhibit reduced hepatic iron levels compared with pups from wild-type mice
• however, pups from heterozygous dams exhibit normal hematologic and serum parameters




Genotype
MGI:4457138
ht2
Allelic
Composition		 Tmprss6tm1Dgen/Tmprss6+
Genetic
Background		 involves: 129P2/OlaHsd * 129S4/SvJae * 129S6/SvEvTac * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tmprss6tm1Dgen mutation (0 available); any Tmprss6 mutation (45 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
hematopoietic system




Genotype
MGI:4457135
cx3
Allelic
Composition		 Hjvtm1Nca/Hjvtm1Nca
Tmprss6tm1Dgen/Tmprss6+
Genetic
Background		 involves: 129P2/OlaHsd * 129S4/SvJae * 129S6/SvEvTac * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Hjvtm1Nca mutation (1 available); any Hjv mutation (19 available)
Tmprss6tm1Dgen mutation (0 available); any Tmprss6 mutation (45 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
homeostasis/metabolism
abnormal iron level ( J:160248 )
• at 8 weeks, mice exhibit increased liver, heart, pancreas, and muscle iron levels compared with wild-type mice
decreased spleen iron level ( J:160248 )
• spleen iron levels are decreased compared to in wild-type mice
• splenic macrophages exhibit decreased iron levels compared with wild-type cells
increased liver iron level ( J:160248 )
• at 8 weeks, specifically in hepatocytes

hematopoietic system
abnormal macrophage morphology ( J:160248 )
• splenic macrophages exhibit decreased iron levels compared with wild-type cells
decreased spleen iron level ( J:160248 )
• spleen iron levels are decreased compared to in wild-type mice
• splenic macrophages exhibit decreased iron levels compared with wild-type cells

liver/biliary system
increased liver iron level ( J:160248 )
• at 8 weeks, specifically in hepatocytes
abnormal hepatocyte morphology ( J:160248 )
• hepatocytes exhibit increased iron accumulation compared with wild-type cells

immune system
abnormal macrophage morphology ( J:160248 )
• splenic macrophages exhibit decreased iron levels compared with wild-type cells
decreased spleen iron level ( J:160248 )
• spleen iron levels are decreased compared to in wild-type mice
• splenic macrophages exhibit decreased iron levels compared with wild-type cells




Genotype
MGI:5441342
cx4
Allelic
Composition		 Hbb-b1tm1Unc/Hbb-b1+
Hbb-b2tm1Unc/Hbb-b2+
Tmprss6tm1Otin/Tmprss6+
Genetic
Background		 involves: 129P2/OlaHsd * C57BL/6 * C57BL/6N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Hbb-b1tm1Unc mutation (2 available); any Hbb-b1 mutation (8 available)
Hbb-b2tm1Unc mutation (2 available); any Hbb-b2 mutation (5 available)
Tmprss6tm1Otin mutation (0 available); any Tmprss6 mutation (45 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
hematopoietic system
abnormal erythrocyte cell number ( J:185154 )
• increased in males and females compared to mutant male and female mice wild-type for Tmprss6 at 6 months of age
abnormal hemoglobin content ( J:185154 )
• increased in males compared to mutant male mice wild-type for Tmprss6
decreased mean corpuscular volume ( J:185154 )
• decreased in males compared to mutant male mice wild-type for Tmprss6 at 6 months of age
abnormal spleen iron level ( J:185154 )
• total spleen iron, but not iron per gram of tissue, is decreased in males compared to mutant male mice wild-type for Tmprss6
abnormal spleen size ( J:185154 )
• reduced size in males compared to mutant male mice wild-type for Tmprss6

homeostasis/metabolism
abnormal spleen iron level ( J:185154 )
• total spleen iron, but not iron per gram of tissue, is decreased in males compared to mutant male mice wild-type for Tmprss6
abnormal circulating erythropoietin level ( J:185154 )
• decreased in males compared to mutant male mice wild-type for Tmprss6
abnormal liver iron level ( J:185154 )
• decreased in males compared to mutant male mice wild-type for Tmprss6

liver/biliary system
abnormal liver iron level ( J:185154 )
• decreased in males compared to mutant male mice wild-type for Tmprss6

immune system
abnormal spleen iron level ( J:185154 )
• total spleen iron, but not iron per gram of tissue, is decreased in males compared to mutant male mice wild-type for Tmprss6
abnormal spleen size ( J:185154 )
• reduced size in males compared to mutant male mice wild-type for Tmprss6




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support. 		last database update
01/13/2026
MGI 6.24 		The Jackson Laboratory