All Phenotypes Thap1<+> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Thap1⁺
wild type
MGI:3049880

Summary

3 genotypes

Allelic Composition	Thap1^em1(IMPC)J/Thap1⁺
Genetic Background	C57BL/6NJ-Thap1^em1(IMPC)J/Mmjax

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Thap1^em1(IMPC)J mutation (2 available); any Thap1 mutation (34 available)

Data Sources

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

vision/eye

abnormal cornea morphology ( J:211773 )

IMPC - JAX

Allelic Composition	Thap1^tm1.2Meeh/Thap1⁺
Genetic Background	involves: 129S/SvEv * BALB/cJ * C3H * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Thap1^tm1.2Meeh mutation (0 available); any Thap1 mutation (34 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

behavior/neurological

abnormal gait ( J:226849 , J:226849 )

	• increase in foot-slips on narrow beam in beam walking challenge (J:226849) • 10% decrease in forepaw base width and 20% increase in front and hind paw overlap (J:226849) • slower in both orienting downwards and descending in pole test (J:226849)
	• 5% increase in forepaw stride length and 17% increase in forepaw base width (J:226849) • faster orienting downwards in pole test (J:226849)

nervous system

decreased brain size ( J:226849 )

• hypocellularity: 40% decrease in cell number

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
torsion dystonia 6		DOID:0090039	OMIM:602629	J:226849

Allelic Composition	Thap1^tm1.1Meeh/Thap1⁺
Genetic Background	involves: 129S/SvEv * C3H * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Thap1^tm1.1Meeh mutation (0 available); any Thap1 mutation (34 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

behavior/neurological

abnormal gait ( J:226849 , J:226849 , J:226849 )

	• increase in foot-slips on narrow beam in beam walking challenge (J:226849) • faster descending in pole test (J:226849)
	• abnormal hind paw base width (J:226849)
	• decrease in stride length of both paws (J:226849)

nervous system

decreased brain size ( J:226849 )

• hypocellularity

• 40% increase in soma volume

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
torsion dystonia 6		DOID:0090039	OMIM:602629	J:226849

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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