Phenotypes associated with this allele

• Allele Symbol: Spag11a⁺
• Allele Name: wild type
• Allele ID: MGI:3049692
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
ht1	Spag11a^em2Mgef/Spag11a^+	C57BL/6NJNcbs-Spag11a^em2Mgef	MGI:8190647

Genotype
MGI:8190647

ht1

• Allelic Composition: Spag11a^em2Mgef/Spag11a⁺
• Genetic Background: C57BL/6NJNcbs-Spag11a^em2Mgef

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

reproductive system

epididymis inflammation ( J:363226 )

♂ • foci of inflammation are seen in the caput epididymis

abnormal caput epididymis morphology ( J:363226 )

♂ • mild hyperplasia is seen in the caput epididymis

abnormal epididymis epithelium morphology ( J:363226 )

♂ • diethylnitrosamine (DEN)-treated mice exhibit mild to moderate mucosal epithelial cell hyperplasia, as well as dysplastic alternations in a few mucosal epithelial cells in the caput epididymis

neoplasm

increased incidence of tumors by chemical induction ( J:363226 )

♂ • DEN-treated mice exhibit mild to moderate mucosal epithelial cell hyperplasia, as well as dysplastic alternations in a few mucosal epithelial cells in the caput epididymis indicating a higher susceptibility towards chemically induced tumorigenesis of the caput epididymis

immune system

epididymis inflammation ( J:363226 )

♂ • foci of inflammation are seen in the caput epididymis

homeostasis/metabolism

increased incidence of tumors by chemical induction ( J:363226 )

♂ • DEN-treated mice exhibit mild to moderate mucosal epithelial cell hyperplasia, as well as dysplastic alternations in a few mucosal epithelial cells in the caput epididymis indicating a higher susceptibility towards chemically induced tumorigenesis of the caput epididymis