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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Ifih1+
wild type
MGI:3048790
Summary 4 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
ht1
 		Ifih1Rgsc422/Ifih1+ D2JJcl.B6JJcl-Ifih1Rgsc422 MGI:5617219
cx2
 		Ifih1Rgsc422/Ifih1+
Ifnar1tm1Agt/Ifnar1+ 		involves: 129S2/SvPas * C57BL/6JJcl * DBA/2JJcl MGI:5617222
cx3
 		Ifih1Rgsc422/Ifih1+
Mavstm1Aki/Mavstm1Aki 		involves: C57BL/6JJcl * DBA/2JJcl MGI:5617220
cx4
 		Ifih1Rgsc422/Ifih1+
Mavstm1Aki/Mavs+ 		involves: C57BL/6JJcl * DBA/2JJcl MGI:5617221


Genotype
MGI:5617219
ht1
Allelic
Composition		 Ifih1Rgsc422/Ifih1+
Genetic
Background		 D2JJcl.B6JJcl-Ifih1Rgsc422
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ifih1Rgsc422 mutation (0 available); any Ifih1 mutation (50 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
decreased survivor rate ( J:209917 )
• 60% of mice die within 24 weeks of birth

growth/size/body
postnatal growth retardation ( J:209917 )

immune system
increased dendritic cell number ( J:209917 )
• increase in the numbers of conventional DCs and plasmacytoid DCs in the spleen
increased plasma cell number ( J:209917 )
• slight increase
abnormal T cell activation ( J:209917 )
• upregulation of an activation marker, CD69, in CD4+ and CD8+ T cells
abnormal macrophage activation involved in immune response ( J:209917 )
• upregulation of the cell surface marker CD86 on macrophages in the spleen suggesting that these cells are activated
abnormal cytokine level ( J:209917 )
• increased production of inflammatory cytokines in the kidney
abnormal chemokine level ( J:209917 )
• increased production of inflammatory chemokines in the kidney
abnormal dendritic cell antigen presentation ( J:209917 )
• upregulation of the cell surface marker CD86 on conventional DCs and plasmacytoid DCs in the spleen suggesting that these cells are activated
increased susceptibility to systemic lupus erythematosus ( J:209917 )
• develop severe multi-organ autoimmune disease
chronic liver inflammation ( J:209917 )
• liver calcification is seen, indicative of chronic inflammation
glomerulonephritis ( J:209917 )
• lupus-like nephritis develops 6-8 weeks after birth
• transfer of bone marrow cells to irradiated wild-type mice induces a milder nephritis
skin inflammation ( J:209917 )
• mild infiltration of polymorphonuclear leukocytes in the haired skin of the forehead

liver/biliary system
chronic liver inflammation ( J:209917 )
• liver calcification is seen, indicative of chronic inflammation

integument
skin inflammation ( J:209917 )
• mild infiltration of polymorphonuclear leukocytes in the haired skin of the forehead

renal/urinary system
glomerulonephritis ( J:209917 )
• lupus-like nephritis develops 6-8 weeks after birth
• transfer of bone marrow cells to irradiated wild-type mice induces a milder nephritis

hematopoietic system
increased dendritic cell number ( J:209917 )
• increase in the numbers of conventional DCs and plasmacytoid DCs in the spleen
increased plasma cell number ( J:209917 )
• slight increase
abnormal T cell activation ( J:209917 )
• upregulation of an activation marker, CD69, in CD4+ and CD8+ T cells
abnormal macrophage activation involved in immune response ( J:209917 )
• upregulation of the cell surface marker CD86 on macrophages in the spleen suggesting that these cells are activated

homeostasis/metabolism
abnormal cytokine level ( J:209917 )
• increased production of inflammatory cytokines in the kidney
abnormal chemokine level ( J:209917 )
• increased production of inflammatory chemokines in the kidney




Genotype
MGI:5617222
cx2
Allelic
Composition		 Ifih1Rgsc422/Ifih1+
Ifnar1tm1Agt/Ifnar1+
Genetic
Background		 involves: 129S2/SvPas * C57BL/6JJcl * DBA/2JJcl
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ifih1Rgsc422 mutation (0 available); any Ifih1 mutation (50 available)
Ifnar1tm1Agt mutation (13 available); any Ifnar1 mutation (62 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
glomerulonephritis ( J:209917 )
• less severe than in mice wild-type for Ifnar1

renal/urinary system
glomerulonephritis ( J:209917 )
• less severe than in mice wild-type for Ifnar1




Genotype
MGI:5617220
cx3
Allelic
Composition		 Ifih1Rgsc422/Ifih1+
Mavstm1Aki/Mavstm1Aki
Genetic
Background		 involves: C57BL/6JJcl * DBA/2JJcl
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ifih1Rgsc422 mutation (0 available); any Ifih1 mutation (50 available)
Mavstm1Aki mutation (0 available); any Mavs mutation (38 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
immune system phenotype ( J:209917 )
N
• mice do not develop glomerulonephritis, enhanced expression of cytokines and chemokines or increased numbers of immune cells in the spleen, unlike mice wild-type for Mavs




Genotype
MGI:5617221
cx4
Allelic
Composition		 Ifih1Rgsc422/Ifih1+
Mavstm1Aki/Mavs+
Genetic
Background		 involves: C57BL/6JJcl * DBA/2JJcl
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ifih1Rgsc422 mutation (0 available); any Ifih1 mutation (50 available)
Mavstm1Aki mutation (0 available); any Mavs mutation (38 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
glomerulonephritis ( J:209917 )
• less severe than in mice wild-type for Mavs

renal/urinary system
glomerulonephritis ( J:209917 )
• less severe than in mice wild-type for Mavs




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
01/06/2026
MGI 6.24 		The Jackson Laboratory