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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Creb5+
wild type
MGI:3048234
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
cx1
 		Atf2tm1Sis/Atf2+
Creb5tm1Sis/Creb5+ 		involves: C57BL/6 * CBA MGI:4421139


Genotype
MGI:4421139
cx1
Allelic
Composition		 Atf2tm1Sis/Atf2+
Creb5tm1Sis/Creb5+
Genetic
Background		 involves: C57BL/6 * CBA
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Atf2tm1Sis mutation (2 available); any Atf2 mutation (89 available)
Creb5tm1Sis mutation (1 available); any Creb5 mutation (19 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
adipose tissue
adipose tissue phenotype ( J:156376 )
N
• unlike in white adipose tissue, no defects are detected in the brown adipose tissue
decreased subcutaneous adipose tissue amount ( J:156376 )
• decrease in the weight of subcutaneous WAT relative to total body weight compared to wild-type controls
decreased white adipose tissue amount ( J:156376 )
• decrease in WAT weight compared to wild-type controls
• decrease in the weight of visceral WAT relative to total body weight compared to wild-type controls

homeostasis/metabolism
improved glucose tolerance ( J:156376 )
• display less high fat diet induced hyperglycemia in an intraperitoneal glucose tolerance test
increased insulin sensitivity ( J:156376 )
• hypoglycemic response to insulin is increased compared to wild-type controls

cellular
abnormal cell differentiation ( J:156376 )
• MEFs display reduced adipocyte differentiation compared to wild-type cells

behavior/neurological
behavior/neurological phenotype ( J:156376 )
N
• despite the decrease in white adipose tissue weight, no difference in cumulative food intake is detected

growth/size/body
growth/size/body region phenotype ( J:156376 )
N
• despite the decrease in white adipose tissue weight, no difference in total body weight is detected

integument
decreased subcutaneous adipose tissue amount ( J:156376 )
• decrease in the weight of subcutaneous WAT relative to total body weight compared to wild-type controls




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
01/20/2026
MGI 6.24 		The Jackson Laboratory