Phenotypes associated with this allele

• Allele Symbol: Card11⁺
• Allele Name: wild type
• Allele ID: MGI:3048105
• Summary: 5 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
ht1	Card11^M4Btlr/Card11^+	C57BL/6J-Card11^M4Btlr	MGI:6113507
ht2	Card11^M5Btlr/Card11^+	C57BL/6J-Card11^M5Btlr	MGI:6113554
ht3	Card11^tm1Vmd/Card11^+	involves: 129S6/SvEvTac * C57BL/6N	MGI:3528448
ht4	Card11^em1Welu/Card11^+	involves: C57BL/6	MGI:6491992
ht5	Card11^em2Welu/Card11^+	involves: C57BL/6	MGI:6491996

Genotype
MGI:6113507

ht1

• Allelic Composition: Card11^M4Btlr/Card11⁺
• Genetic Background: C57BL/6J-Card11^M4Btlr

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

hematopoietic system

decreased B-1a cell number ( J:254856 )

increased B-1b cell number ( J:254856 )

immune system

decreased B-1a cell number ( J:254856 )

increased B-1b cell number ( J:254856 )

Genotype
MGI:6113554

ht2

• Allelic Composition: Card11^M5Btlr/Card11⁺
• Genetic Background: C57BL/6J-Card11^M5Btlr

immune system

increased B-1 B cell number ( J:254879 )

increased B-1a cell number ( J:254879 )

decreased IgM level ( J:254879 )

• decreased T-independent antibody response to 4-hydroxy-3-nitrophenylacetyl-Ficoll (NP-Ficoll)

impaired humoral immune response ( J:254879 )

• decreased T-independent antibody response to 4-hydroxy-3-nitrophenylacetyl-Ficoll (NP-Ficoll)

hematopoietic system

increased B-1 B cell number ( J:254879 )

increased B-1a cell number ( J:254879 )

decreased IgM level ( J:254879 )

• decreased T-independent antibody response to 4-hydroxy-3-nitrophenylacetyl-Ficoll (NP-Ficoll)

Genotype
MGI:3528448

ht3

• Allelic Composition: Card11^tm1Vmd/Card11⁺
• Genetic Background: involves: 129S6/SvEvTac * C57BL/6N

immune system

decreased B cell proliferation ( J:95800 )

• mitogen-induced proliferation is impaired and addition of exogenous IL-2 does not restore proliferation

hematopoietic system

decreased B cell proliferation ( J:95800 )

• mitogen-induced proliferation is impaired and addition of exogenous IL-2 does not restore proliferation

cellular

decreased B cell proliferation ( J:95800 )

• mitogen-induced proliferation is impaired and addition of exogenous IL-2 does not restore proliferation

Genotype
MGI:6491992

ht4

• Allelic Composition: Card11^em1Welu/Card11⁺
• Genetic Background: involves: C57BL/6

immune system

decreased transitional stage T1 B cell number ( J:292926 )

decreased transitional stage T3 B cell number ( J:292926 )

increased transitional stage T2 B cell number ( J:292926 )

decreased marginal zone B cell number ( J:292926 )

impaired humoral immune response ( J:292926 )

• mice show intermediate defects in the marginal zone and B1 B cell development, and the transitional B cell populations from T1 to T3 compared to homozygous mice

hematopoietic system

decreased transitional stage T1 B cell number ( J:292926 )

decreased transitional stage T3 B cell number ( J:292926 )

increased transitional stage T2 B cell number ( J:292926 )

decreased marginal zone B cell number ( J:292926 )

Genotype
MGI:6491996

ht5

• Allelic Composition: Card11^em2Welu/Card11⁺
• Genetic Background: involves: C57BL/6

immune system

increased B-1 B cell number ( J:292926 )

• B1 B cell development is intermediately enhanced compared with wild-type and homozygous mutants

increased marginal zone B cell number ( J:292926 )

• marginal zone B cell development is intermediately enhanced compared with wild-type and homozygous mutants

hematopoietic system

increased B-1 B cell number ( J:292926 )

• B1 B cell development is intermediately enhanced compared with wild-type and homozygous mutants

increased marginal zone B cell number ( J:292926 )

• marginal zone B cell development is intermediately enhanced compared with wild-type and homozygous mutants