Phenotypes associated with this allele

• Allele Symbol: Pds5b⁺
• Allele Name: wild type
• Allele ID: MGI:3047993
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
cx1	Pds5a^Gt(RRM243)Byg/Pds5a^Gt(RRM243)Byg Pds5b^tm1Jmi/Pds5b^+	involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * C57BL/6	MGI:3847294

Genotype
MGI:3847294

cx1

• Allelic Composition: Pds5a^{Gt(RRM243)Byg}/Pds5a^{Gt(RRM243)Byg}; Pds5b^tm1Jmi/Pds5b⁺
• Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

Pds5a^{Gt(RRM243)Byg}/Pds5a^{Gt(RRM243)Byg}, Pds5a^{Gt(RRM243)Byg}/Pds5a^{Gt(RRM243)Byg} Pds5b^tm1Jmi/Pds5b⁺ and Pds5a^{Gt(RRM243)Byg}/Pds5a⁺ Pds5b^tm1Jmi/Pds5b^tm1Jmi mice manifest cardiac abnormalities similar to those observed in Cornelia de Lange syndrome

mortality/aging

embryonic lethality during organogenesis, complete penetrance ( J:148890 )

• mice die by E12.5

cardiovascular system

abnormal heart morphology ( J:148890 )

• severe

thin ventricle myocardium compact layer ( J:148890 )

• the compact ventricular myocardium is thin unlike in wild-type mice

conotruncal ridge hypoplasia ( J:148890 )

common truncal valve ( J:148890 )

• failed to separate aortic and pulmonic valve leaflets and the aorticopulmonary septum is absent unlike in wild-type mice

persistent truncus arteriosus ( J:148890 )

common atrioventricular valve ( J:148890 )

• endocardial cushions fail to develop separate aortic and pulmonic valve leaflets

dilated heart atrium ( J:148890 )

absent aorticopulmonary septum ( J:148890 )

complete atrioventricular septal defect ( J:148890 )

• mice develop a common atrioventricular canal unlike in wild-type mice

abnormal interventricular septum morphology ( J:148890 )

• hypoplasic or aplastic

nervous system

abnormal nervous system morphology ( J:148890 )

• mice exhibit peripheral nervous system defects

abnormal enteric nervous system morphology ( J:148890 )

• at E12.5, enteric nervous system precursors fail to migrate much beyond the ileocecal junction unlike in wild-type mice and more severely than in Pds5a^{Gt(RRM243)Byg} homozygotes

vision/eye

small lens ( J:148890 )

• agenesis and sometimes lens hypoplasia are observed at E11.5 and E12.5

abnormal eye development ( J:148890 )

• at E10.5, reduced contact between the lens placode and the optic vesicle is observed compared to in wild-type mice

abnormal lens development ( J:148890 )

• the peripheral sections of the lens placode are thinner than normal and have fewer cells than in wild-type mice

abnormal optic vesicle formation ( J:148890 )

• distorted shape

growth/size/body

embryonic growth retardation ( J:148890 )

• severe

embryo

embryonic growth retardation ( J:148890 )

• severe

muscle

thin ventricle myocardium compact layer ( J:148890 )

• the compact ventricular myocardium is thin unlike in wild-type mice