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| Caption | A: A section of a wild-type mouse heart demonstrates the intact ventricular septum and its relationship to the aortic and tricuspid valves. B-D: Sections of Pds5aGt(RRM243)Byg/Pds5aGt(RRM243)Byg (Pds5A-/-) mutant hearts showing: (B) a perimembranous ventricular septal defect (VSD); (C) the pulmonary valve and artery in a heart with double outlet right ventricle; (D) the aorta arising from the right ventricle of the same heart with a muscular conus between the aortic and mitral valve (arrowhead). Arrows indicate the respective defects. Scale bar: 0.5 mm. E-J: Severe cardiac defects in Pds5aGt(RRM243)Byg/Pds5a+ Pds5btm1Jmi/Pds5btm1Jmi and Pds5aGt(RRM243)Byg/Pds5aGt(RRM243)Byg Pds5btm1Jmi/Pds5b+ embryos. E: A section from wild-type E12.5 embryonic heart shows the separation of aorta and pulmonary artery and the developing aortic valves (arrow). F: A Pds5aGt(RRM243)Byg/Pds5aGt(RRM243)Byg Pds5btm1Jmi/Pds5b+ E12.5 embryonic heart shows the underdeveloped endocardial cushion of the outflow tract and the non-septated aorta and pulmonary artery (i.e., truncus arteriosus). G: Normal association of the atrial and ventricular septae with the endocardiac cushion and valve morphogenesis in a wild-type E12.5 heart. H: A Pds5aGt(RRM243)Byg/Pds5a+ Pds5btm1Jmi/Pds5btm1Jmi E12.5 heart deomnstrates the dilated atria and underdeveloped endocardial cushion with no valve formation, and failure of atrioventricular canal septation. I: Wild-type E12.5 heart with a compact myocardial layer of normal thickness. J: A Pds5aGt(RRM243)Byg/Pds5aGt(RRM243)Byg Pds5btm1Jmi/Pds5b+ heart has a thin compact myocardium. Doubleheaded arrows in (I,J) indicate the compact myocardial layer. Ao, aorta; PA, pulmonary artery; RA, right atrium; LA, left atrium; RV, right ventricle; LV, left ventricle; EC, endocardial cushion; T, trabecular myocardium; C, compact myocardium. | ||||||||
| Copyright | This image is from Zhang B, PLoS ONE 2009;4(5):e5232, and is displayed under the terms of the Creative Commons Attribution 4.0 International License. J:148890 | ||||||||
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Associated Genotypes |
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 04/30/2024 MGI 6.23 |
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