About   Help   FAQ
Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Dnmt3btm5.2Enl
targeted mutation 5.2, En Li
MGI:3047834
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Dnmt3btm5.2Enl/Dnmt3btm5.2Enl involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ * FVB/N MGI:3047843
cn2
 		Alpltm1(cre)Nagy/Alpl+
Dnmt3btm5.1Enl/Dnmt3btm5.2Enl 		involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ * FVB/N MGI:3047842


Genotype
MGI:3047843
hm1
Allelic
Composition		 Dnmt3btm5.2Enl/Dnmt3btm5.2Enl
Genetic
Background		 involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ * FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Dnmt3btm5.2Enl mutation (0 available); any Dnmt3b mutation (50 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
prenatal lethality, complete penetrance ( J:91108 )
• no viable homozygotes are recovered at birth

embryo
decreased embryo size ( J:91108 )
• embryos are growth impaired
open neural tube ( J:91108 )
• rostral neural tube closure defects are seen in homozygous embryos

growth/size/body
decreased embryo size ( J:91108 )
• embryos are growth impaired

nervous system
open neural tube ( J:91108 )
• rostral neural tube closure defects are seen in homozygous embryos




Genotype
MGI:3047842
cn2
Allelic
Composition		 Alpltm1(cre)Nagy/Alpl+
Dnmt3btm5.1Enl/Dnmt3btm5.2Enl
Genetic
Background		 involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ * FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Alpltm1(cre)Nagy mutation (6 available); any Alpl mutation (351 available)
Dnmt3btm5.1Enl mutation (3 available); any Dnmt3b mutation (50 available)
Dnmt3btm5.2Enl mutation (0 available); any Dnmt3b mutation (50 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
reproductive system
reproductive system phenotype ( J:91108 )
N
• crossing mutant males or females with wild-type mice results in the generation of litters of healthy pups




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support. 		last database update
04/30/2024
MGI 6.23 		The Jackson Laboratory