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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Dnmt3btm5.2Enl
targeted mutation 5.2, En Li
MGI:3047834
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Dnmt3btm5.2Enl/Dnmt3btm5.2Enl involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ * FVB/N MGI:3047843
cn2
 		Alpltm1(cre)Nagy/Alpl+
Dnmt3btm5.1Enl/Dnmt3btm5.2Enl 		involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ * FVB/N MGI:3047842


Genotype
MGI:3047843
hm1
Allelic
Composition		 Dnmt3btm5.2Enl/Dnmt3btm5.2Enl
Genetic
Background		 involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ * FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Dnmt3btm5.2Enl mutation (0 available); any Dnmt3b mutation (53 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
prenatal lethality, complete penetrance ( J:91108 )
• no viable homozygotes are recovered at birth

embryo
decreased embryo size ( J:91108 )
• embryos are growth impaired
open neural tube ( J:91108 )
• rostral neural tube closure defects are seen in homozygous embryos

growth/size/body
decreased embryo size ( J:91108 )
• embryos are growth impaired

nervous system
open neural tube ( J:91108 )
• rostral neural tube closure defects are seen in homozygous embryos




Genotype
MGI:3047842
cn2
Allelic
Composition		 Alpltm1(cre)Nagy/Alpl+
Dnmt3btm5.1Enl/Dnmt3btm5.2Enl
Genetic
Background		 involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ * FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Alpltm1(cre)Nagy mutation (6 available); any Alpl mutation (350 available)
Dnmt3btm5.1Enl mutation (3 available); any Dnmt3b mutation (53 available)
Dnmt3btm5.2Enl mutation (0 available); any Dnmt3b mutation (53 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
reproductive system
reproductive system phenotype ( J:91108 )
N
• crossing mutant males or females with wild-type mice results in the generation of litters of healthy pups




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
09/30/2025
MGI 6.24 		The Jackson Laboratory