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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Ptk7+
wild type
MGI:3047811
Summary 3 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
cx1
 		Celsr1Crsh/Celsr1+
Ptk7chz/Ptk7+ 		involves: 101/H * BALB/c * BALB/cAnN * C3H/HeH MGI:4830334
cx2
 		Vangl2Lp/Vangl2+
Ptk7Gt(Betageo)1Matl/Ptk7+ 		involves: 129P2/Ola * C57BL/6 * LPT/LeJ MGI:3047813
cx3
 		Ptk7chz/Ptk7+
Vangl2Lp/Vangl2+ 		involves: A * BALB/cAnN * C3H/HeH MGI:4830332


Genotype
MGI:4830334
cx1
Allelic
Composition		 Celsr1Crsh/Celsr1+
Ptk7chz/Ptk7+
Genetic
Background		 involves: 101/H * BALB/c * BALB/cAnN * C3H/HeH
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Celsr1Crsh mutation (2 available); any Celsr1 mutation (144 available)
Ptk7chz mutation (2 available); any Ptk7 mutation (58 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
embryo
spina bifida ( J:163834 )
• 6% display spina bifida

nervous system
spina bifida ( J:163834 )
• 6% display spina bifida




Genotype
MGI:3047813
cx2
Allelic
Composition		 Vangl2Lp/Vangl2+
Ptk7Gt(Betageo)1Matl/Ptk7+
Genetic
Background		 involves: 129P2/Ola * C57BL/6 * LPT/LeJ
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ptk7Gt(Betageo)1Matl mutation (0 available); any Ptk7 mutation (58 available)
Vangl2Lp mutation (2 available); any Vangl2 mutation (30 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
hearing/vestibular/ear
hearing/vestibular/ear phenotype ( J:91298 )
N
• hair cell stereociliary bundle morphology is mostly unaffected

nervous system
spina bifida ( J:91298 )
• spina bifida is seen in 94% of double heterozygotes

embryo
spina bifida ( J:91298 )
• spina bifida is seen in 94% of double heterozygotes




Genotype
MGI:4830332
cx3
Allelic
Composition		 Ptk7chz/Ptk7+
Vangl2Lp/Vangl2+
Genetic
Background		 involves: A * BALB/cAnN * C3H/HeH
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ptk7chz mutation (2 available); any Ptk7 mutation (58 available)
Vangl2Lp mutation (2 available); any Vangl2 mutation (30 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
embryo
spina bifida ( J:163834 )
• 23% exhibit spina bifida or craniorachischisis
craniorachischisis ( J:163834 )
• 23% exhibit spina bifida or craniorachischisis

nervous system
spina bifida ( J:163834 )
• 23% exhibit spina bifida or craniorachischisis
craniorachischisis ( J:163834 )
• 23% exhibit spina bifida or craniorachischisis




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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
03/18/2025
MGI 6.24 		The Jackson Laboratory