Phenotypes associated with this allele
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Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cd79atm5.1Cgn mutation
(0 available);
any
Cd79a mutation
(22 available)
Cd79atm5Cgn mutation
(0 available);
any
Cd79a mutation
(22 available)
Tg(Cr2-cre)3Cgn mutation
(2 available)
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hematopoietic system
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• B cell numbers are reduced 50% in the bone marrow, by about 2/3 in follicular and marginal zones of the spleen, and strongly reduced in the inguinal lymph nodes
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immune system
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• B cell numbers are reduced 50% in the bone marrow, by about 2/3 in follicular and marginal zones of the spleen, and strongly reduced in the inguinal lymph nodes
|
|
Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cd79atm5.1Cgn mutation
(0 available);
any
Cd79a mutation
(22 available)
Cd79atm5Cgn mutation
(0 available);
any
Cd79a mutation
(22 available)
Tg(Mx1-cre)1Cgn mutation
(7 available)
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hematopoietic system
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• about 2 weeks after p(I)p(C) injections an almost complete block in B cell development is seen
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• about 2 weeks after p(I)p(C) injections most of the B cells are lost from the spleen and lymph nodes
• marginal zone B cells were not affected probably as a result of replenishment from cells that escaped cre mediated recombination
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• in the spleen almost all immature spleen cells are missing
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immune system
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• about 2 weeks after p(I)p(C) injections an almost complete block in B cell development is seen
|
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• about 2 weeks after p(I)p(C) injections most of the B cells are lost from the spleen and lymph nodes
• marginal zone B cells were not affected probably as a result of replenishment from cells that escaped cre mediated recombination
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• in the spleen almost all immature spleen cells are missing
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