Phenotypes associated with this allele
Allelic Composition |
Pbx2tm1Mlc/Pbx2tm1Mlc
|
|
Genetic Background |
either: 129S/Sv or (involves: 129S/Sv * C57BL/6) |
|
Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Pbx2tm1Mlc mutation
(0 available);
any
Pbx2 mutation
(14 available)
|
|
|
hematopoietic system
N |
• no difference in hemoglobin content, erythrocyte indices, or leukocyte or platelet counts are detected
|
immune system
N |
• no difference in absolute or relative B or T cell numbers is detected
|
skeleton
N |
• no defect in skeletal or cartilaginous development is detected
|
normal phenotype
|
• homozygotes are viable with normal body and organ weights, fertility, and longevity
|
|
Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Foxg1tm1(cre)Skm mutation
(2 available);
any
Foxg1 mutation
(28 available)
Pbx1tm1Koss mutation
(0 available);
any
Pbx1 mutation
(40 available)
Pbx2tm1Mlc mutation
(0 available);
any
Pbx2 mutation
(14 available)
|
|
|
mortality/aging
craniofacial
|
• abnormal maxillary palatal and palatine process
|
|
• the premaxillary process is absent
|
respiratory system
digestive/alimentary system
|
• abnormal maxillary palatal and palatine process
|
skeleton
|
• abnormal maxillary palatal and palatine process
|
|
• the premaxillary process is absent
|
growth/size/body
|
• abnormal maxillary palatal and palatine process
|
|
Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Pbx1tm1Koss mutation
(0 available);
any
Pbx1 mutation
(40 available)
Pbx2tm1Mlc mutation
(0 available);
any
Pbx2 mutation
(14 available)
Tg(Tcfap2a-cre)1Will mutation
(0 available)
|
|
|
craniofacial
|
• cleft lip and/or palate
|
|
• cleft lip and/or palate
|
digestive/alimentary system
|
• cleft lip and/or palate
|
growth/size/body
|
• cleft lip and/or palate
|
|
• cleft lip and/or palate
|
|
Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Foxg1tm1(cre)Skm mutation
(2 available);
any
Foxg1 mutation
(28 available)
Pbx1tm1Koss mutation
(0 available);
any
Pbx1 mutation
(40 available)
Pbx2tm1Mlc mutation
(0 available);
any
Pbx2 mutation
(14 available)
|
|
|
craniofacial
cellular
|
• in the nasal epithelial at E10.75
|
growth/size/body
|
Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Nkx2-5tm2(cre)Rph mutation
(1 available);
any
Nkx2-5 mutation
(21 available)
Pbx1tm1Koss mutation
(0 available);
any
Pbx1 mutation
(40 available)
Pbx2tm1Mlc mutation
(0 available);
any
Pbx2 mutation
(14 available)
|
|
|
hematopoietic system
|
• hypoplastic and fragmented
• more severe than in mutant mice wild-type for Pbx2
|
immune system
|
• hypoplastic and fragmented
• more severe than in mutant mice wild-type for Pbx2
|
|
Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gt(ROSA)26Sortm2(Wnt1/GFP)Amc mutation
(1 available);
any
Gt(ROSA)26Sor mutation
(944 available)
Pbx1tm1Koss mutation
(0 available);
any
Pbx1 mutation
(40 available)
Pbx2tm1Mlc mutation
(0 available);
any
Pbx2 mutation
(14 available)
Tg(Tcfap2a-cre)1Will mutation
(0 available)
|
|
|
craniofacial
N |
• the cleft lip phenotype observed in Pbx1tm1.1Koss/Pbx1tm1.1Koss Pbx2tm1Mlc/Pbx2+ Tg(Tcfap2a*-cre)1Will is rescued
|
|
Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
H2az2Tg(Wnt1-cre)11Rth mutation
(2 available);
any
H2az2 mutation
(26 available)
Pbx1tm1Koss mutation
(0 available);
any
Pbx1 mutation
(40 available)
Pbx2tm1Mlc mutation
(0 available);
any
Pbx2 mutation
(14 available)
|
|
|
mortality/aging
craniofacial
nervous system
N |
• cranial neural crest cell migration and olfactory placodes are normal
|
digestive/alimentary system
growth/size/body
|
Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Pbx1tm1Mlc mutation
(0 available);
any
Pbx1 mutation
(40 available)
Pbx2tm1Mlc mutation
(0 available);
any
Pbx2 mutation
(14 available)
Pbx3tm1Mlc mutation
(0 available);
any
Pbx3 mutation
(35 available)
|
|
|
craniofacial
digestive/alimentary system
mortality/aging
growth/size/body
|
Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Pbx1tm1Mlc mutation
(0 available);
any
Pbx1 mutation
(40 available)
Pbx2tm1Mlc mutation
(0 available);
any
Pbx2 mutation
(14 available)
|
|
|
craniofacial
|
• bilateral or unilateral
|
|
• abnormally fused at E11.5 with persistence of an abnormal bridge connecting their posterior aspects to the anterior maxillary process
|
|
• abnormally fused at E11.5 with persistence of an abnormal bridge connecting their posterior aspects to the anterior maxillary process
|
|
• abnormally fused at E11.5 with persistence of an abnormal bridge connecting their posterior aspects to the anterior maxillary process
|
|
• bilateral or unilateral cleft lip and/or palate
|
|
• bilateral or unilateral cleft lip and/or palate
|
homeostasis/metabolism
skeleton
|
• bilateral or unilateral
|
digestive/alimentary system
growth/size/body
|
• bilateral or unilateral cleft lip and/or palate
|
|
• bilateral or unilateral cleft lip and/or palate
|