About   Help   FAQ
Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Tg(Mpz-cre)4Brn
transgene insertion 4, Anton Berns
MGI:3047266
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
cn1
 		Nf2tm2Gth/Nf2tm2Gth
Tg(Mpz-cre)4Brn/0 		involves: 129P2/OlaHsd * FVB/N MGI:3850391
cn2
 		Nf2tm1Gth/Nf2tm2Gth
Tg(Mpz-cre)4Brn/0 		involves: 129P2/OlaHsd * FVB/N MGI:3850402


Genotype
MGI:3850391
cn1
Allelic
Composition		 Nf2tm2Gth/Nf2tm2Gth
Tg(Mpz-cre)4Brn/0
Genetic
Background		 involves: 129P2/OlaHsd * FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Nf2tm2Gth mutation (3 available); any Nf2 mutation (67 available)
Tg(Mpz-cre)4Brn mutation (0 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
premature death ( J:63264 )
• all mice die by 19 months of age

neoplasm
increased Schwannoma incidence ( J:63264 )
• 66% of mice develop schwannomas

nervous system
increased Schwannoma incidence ( J:63264 )
• 66% of mice develop schwannomas




Genotype
MGI:3850402
cn2
Allelic
Composition		 Nf2tm1Gth/Nf2tm2Gth
Tg(Mpz-cre)4Brn/0
Genetic
Background		 involves: 129P2/OlaHsd * FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Nf2tm1Gth mutation (1 available); any Nf2 mutation (67 available)
Nf2tm2Gth mutation (3 available); any Nf2 mutation (67 available)
Tg(Mpz-cre)4Brn mutation (0 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support. 		last database update
09/30/2025
MGI 6.24 		The Jackson Laboratory