Phenotypes associated with this allele
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Zdhhc8tm1Kara mutation
(0 available);
any
Zdhhc8 mutation
(25 available)
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behavior/neurological
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• homozygous females travel and rear significantly less and avoid the center more in an open field test
• homozygous males show a milder decrease in locomotor activity in an open field test
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nervous system
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• homozygous female but not male mutants display a significant reduction in prepulse inhibition compared to wild-type littermates at 78 db
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Zdhhc8tm1Kara mutation
(0 available);
any
Zdhhc8 mutation
(25 available)
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nervous system
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• reduction in dendritic complexity in primary cultured neurons, with hippocampal neurons exhibiting a 19.5% decrease in the number of primary dendrites and a 41% decrease in the number of branch points
• CA1 pyramidal neurons show a simplification in the dendritic arbors, with 8 week old mice showing a 21% decrease in the total number of branch points in the basal dendritic tree of CA1 neurons
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• the number of mushroom spines in primary cultured neurons is reduced by 43%
• reduction in the mushroom spine density in CA1 pyramidal neurons
• however, no changes in the width and length of primary culture neurons and CA1 pyramidal spines are seen
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• reduction in the density of glutamatergic synaptic contacts in vitro and in vivo
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Allelic
Composition |
Zdhhc8tm1Kara/Zdhhc8+
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Genetic
Background |
involves: 129/Sv * C57BL/6 |
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Zdhhc8tm1Kara mutation
(0 available);
any
Zdhhc8 mutation
(25 available)
|
|
|
behavior/neurological
|
|
• heterozygous females travel and rear significantly less and avoid the center more in an open field test
|
Allelic
Composition |
Zdhhc8tm1Kara/Zdhhc8+
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|
Genetic
Background |
Not Specified |
|
| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Zdhhc8tm1Kara mutation
(0 available);
any
Zdhhc8 mutation
(25 available)
|
|
|
nervous system
|
|
• reduction in dendritic complexity in primary cultured neurons, with hippocampal neurons exhibiting a 12% decrease in the number of primary dendrites and a 37% decrease in the number of branch points
• CA1 pyramidal neurons show a simplification in the dendritic arbors, with 8 week old mice showing a 19% decrease in the total number of branch points in the basal dendritic tree of CA1 neurons
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• the number of mushroom spines in mutant neurons is reduced by 40%
• reduction in the mushroom spine density in CA1 pyramidal neurons
• however, no changes in the width and length of primary cultured neurons and CA1 pyramidal spines are seen
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• reduction in the density of glutamatergic synaptic contacts
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Analysis Tools