Phenotypes associated with this allele
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mybtm1.1Cgn mutation
(0 available);
any
Myb mutation
(53 available)
Mybtm1Cgn mutation
(1 available);
any
Myb mutation
(53 available)
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normal phenotype
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• compound heterozygotes are healthy and fertile
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mybtm1.1Cgn mutation
(0 available);
any
Myb mutation
(53 available)
Mybtm1Cgn mutation
(1 available);
any
Myb mutation
(53 available)
Tg(Lck-cre)548Jxm mutation
(2 available)
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hematopoietic system
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• thymus cellularity is reduced
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• the absolute number of double positive cells is decreased
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• the absolute number of CD4 single positive cells is decreased
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immune system
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• thymus cellularity is reduced
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• the absolute number of double positive cells is decreased
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• the absolute number of CD4 single positive cells is decreased
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endocrine/exocrine glands
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• thymus cellularity is reduced
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mybtm1Cgn mutation
(1 available);
any
Myb mutation
(53 available)
Tg(Lck-cre)548Jxm mutation
(2 available)
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hematopoietic system
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• thymus cellularity is reduced about 75%
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• the absolute number of double positive cells is decreased about 80%
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• the absolute number of CD4 single positive cells is decreased about 80%
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immune system
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• thymus cellularity is reduced about 75%
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• the absolute number of double positive cells is decreased about 80%
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• the absolute number of CD4 single positive cells is decreased about 80%
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endocrine/exocrine glands
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• thymus cellularity is reduced about 75%
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hematopoietic system
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• thymus cellularity is reduced about 97%
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• the absolute number of double negative cells is decreased about 40% however the proportion of double negative cells is increased to about 60% of total thymocytes
• about 90% of the double negative cells are CD44-CD25+ DN3 cells
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• the absolute number of double positive cells is greatly decreased
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• a block in thymocyte maturation at the DN3 stage or in the transition from DN3 to DN4 appears to occur
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• the absolute number of CD4 single positive cells is greatly decreased
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• the absolute number of CD8 single positive cells is greatly decreased
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• the number of gamma delta TCR bearing thymocytes is decreased
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immune system
|
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• thymus cellularity is reduced about 97%
|
|
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• the absolute number of double negative cells is decreased about 40% however the proportion of double negative cells is increased to about 60% of total thymocytes
• about 90% of the double negative cells are CD44-CD25+ DN3 cells
|
|
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• the absolute number of double positive cells is greatly decreased
|
|
|
• a block in thymocyte maturation at the DN3 stage or in the transition from DN3 to DN4 appears to occur
|
|
|
• the absolute number of CD4 single positive cells is greatly decreased
|
|
|
• the absolute number of CD8 single positive cells is greatly decreased
|
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• the number of gamma delta TCR bearing thymocytes is decreased
|
endocrine/exocrine glands
|
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• thymus cellularity is reduced about 97%
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Analysis Tools
