Phenotypes associated with this allele
nervous system
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• an additional lacZ positive glomerulus is detected on the dorsolateral side of the olfactory bulb, only the glomerulus on the medial side is detected in controls
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Omptm1(cre)Jae mutation
(0 available);
any
Omp mutation
(27 available)
Robo2tm1Rilm mutation
(1 available);
any
Robo2 mutation
(101 available)
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behavior/neurological
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• display a reduced aversive response and decreased innate avoidance behavior to the predator odorant TMT, a component of fox feces
• however, the responses to 2MB acid, an odorant of spoiled food, are similar to controls
• mice can be conditioned to respond to TMT indicating there is not a defect in detection of this odorant
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Omptm1(cre)Jae mutation
(0 available);
any
Omp mutation
(27 available)
Or5d18tm1.1Jfcl mutation
(0 available);
any
Or5d18 mutation
(14 available)
Robo2tm1Rilm mutation
(1 available);
any
Robo2 mutation
(101 available)
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nervous system
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• olfactory sensory neurons expressing GFP are shifted ventrally in the olfactory bulb compared to controls
• in some mice (3 of 12) a third GFP positive glomerulus is detected on the lateral side of the olfactory bulb, a third glomerulus is only seen in 1 control
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Omptm1(cre)Jae mutation
(0 available);
any
Omp mutation
(27 available)
Or51b4tm1.1Jfcl mutation
(0 available);
any
Or51b4 mutation
(10 available)
Robo2tm1Rilm mutation
(1 available);
any
Robo2 mutation
(101 available)
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nervous system
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• location of glomeruli from olfactory sensory neurons expressing lacZ is similar to controls
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Omptm1(cre)Jae mutation
(0 available);
any
Omp mutation
(27 available)
Pgrmc1tm1.1Jjp mutation
(0 available);
any
Pgrmc1 mutation
(10 available)
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behavior/neurological
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• female mice exhibit constant attraction behavior to recombinant major urinary proteins (rMUPs), in both estrus and diestrus unlike wild-type mice
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nervous system
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N |
• vomeronasal sensory neurons (VSNs) from ovariectomized mice exhibit normal response to recombinant major urinary proteins (rMUPs), even in the presence of diestrous levels of P4
• VSNs from diestrous-staged female mice exhibit responsiveness to rMUPs across both estrus and diestrus
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taste/olfaction
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N |
• vomeronasal sensory neurons (VSNs) from ovariectomized mice exhibit normal response to recombinant major urinary proteins (rMUPs), even in the presence of diestrous levels of P4
• VSNs from diestrous-staged female mice exhibit responsiveness to rMUPs across both estrus and diestrus
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Kirrel2tm2c(KOMP)Wtsi mutation
(0 available);
any
Kirrel2 mutation
(24 available)
Omptm1(cre)Jae mutation
(0 available);
any
Omp mutation
(27 available)
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nervous system
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• adult mice show defects in glomeruli formation with significantly larger and fewer glomeruli in the posterior region of the accessory olfactory bulb (AOB) relative to controls
• in contrast, the anterior AOB region contains glomeruli of normal size and number
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Analysis Tools
