All Phenotypes Igh-J<tm1(VDJ-17.2.25)Wabl> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Igh-J^{tm1(VDJ-17.2.25)Wabl}
targeted mutation 1, Matthias Wabl
MGI:3045610

Summary

1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
cx1	Igh-J^tm1Dhu/Igh-J^{tm1(VDJ-17.2.25)Wabl} Igk^tm1Dhu/Igk^tm1Dhu	Not Specified	MGI:3045805

Allelic Composition	Igh-J^tm1Dhu/Igh-J^{tm1(VDJ-17.2.25)Wabl} Igk^tm1Dhu/Igk^tm1Dhu
Genetic Background	Not Specified

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Igh-J^tm1Dhu mutation (1 available); any Igh-J mutation (13 available)
Igh-J^{tm1(VDJ-17.2.25)Wabl} mutation (0 available); any Igh-J mutation (13 available)
Igk^tm1Dhu mutation (1 available); any Igk mutation (25 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

hematopoietic system

abnormal B cell differentiation ( J:33628 )

• precursor B cells and B lymphocytes are reduced by 1/3 to 1/2

abnormal immature B cell morphology ( J:89757 )

• 80% of bone marrow B cells have an immature phenotype

• rapid turnover

immune system

abnormal B cell differentiation ( J:33628 )

• precursor B cells and B lymphocytes are reduced by 1/3 to 1/2

abnormal immature B cell morphology ( J:89757 )

• 80% of bone marrow B cells have an immature phenotype

• rapid turnover

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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