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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Map3k4tm1Flv
targeted mutation 1, Richard A Flavell
MGI:3044978
Summary 5 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Map3k4tm1Flv/Map3k4tm1Flv involves: 129S6/SvEvTac * C57BL/6 MGI:3044999
hm2
 		Map3k4tm1Flv/Map3k4tm1Flv involves: 129S6/SvEvTac * C57BL/6J MGI:4361430
ht3
 		Map3k4byg/Map3k4tm1Flv involves: 129S6/SvEvTac * C3H/HeH * C57BL/6J MGI:4361427
cx4
 		Map3k4tm1Flv/Map3k4+
X/SryAKR/J 		B6.Cg-Map3k4tm1Flv Chr YAKR MGI:4361432
cx5
 		Gadd45gtm1Jni/Gadd45g+
Map3k4tm1Flv/Map3k4+ 		involves: 129P2/OlaHsd * 129S6/SvEvTac * C57BL/6J MGI:5461495


Genotype
MGI:3044999
hm1
Allelic
Composition		 Map3k4tm1Flv/Map3k4tm1Flv
Genetic
Background		 involves: 129S6/SvEvTac * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Map3k4tm1Flv mutation (1 available); any Map3k4 mutation (79 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
perinatal lethality, incomplete penetrance ( J:90112 )
• fewer homozygotes born than anticipated

growth/size/body
decreased body size ( J:90112 )
• reduced body size of surviving homozygotes but no other obvious defects

immune system
abnormal T-helper 1 physiology ( J:90112 )
• IFN-gamma production reduced about 50% both in response to T cell receptor stimulation and to Il12/Il18 stimulation
decreased interferon-gamma secretion ( J:90112 )
• IFN-gamma production reduced about 3 fold

hematopoietic system
abnormal T-helper 1 physiology ( J:90112 )
• IFN-gamma production reduced about 50% both in response to T cell receptor stimulation and to Il12/Il18 stimulation




Genotype
MGI:4361430
hm2
Allelic
Composition		 Map3k4tm1Flv/Map3k4tm1Flv
Genetic
Background		 involves: 129S6/SvEvTac * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Map3k4tm1Flv mutation (1 available); any Map3k4 mutation (79 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype

XY gonad in Map3k4tm1Flv/Map3k4tm1Flv embryos exhibits overt ovarian morphology

reproductive system
primary sex reversal ( J:153050 )
• XY gonads are ovarian in appearance




Genotype
MGI:4361427
ht3
Allelic
Composition		 Map3k4byg/Map3k4tm1Flv
Genetic
Background		 involves: 129S6/SvEvTac * C3H/HeH * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Map3k4byg mutation (1 available); any Map3k4 mutation (79 available)
Map3k4tm1Flv mutation (1 available); any Map3k4 mutation (79 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
reproductive system
primary sex reversal ( J:153050 )
• XY gonads are ovarian in appearance

nervous system

embryo




Genotype
MGI:4361432
cx4
Allelic
Composition		 Map3k4tm1Flv/Map3k4+
X/SryAKR/J
Genetic
Background		 B6.Cg-Map3k4tm1Flv Chr YAKR
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Map3k4tm1Flv mutation (1 available); any Map3k4 mutation (79 available)
SryAKR/J mutation (6 available); any Sry mutation (54 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype

Ovotestis development in Map3k4tm1Flv/Map3k4+ X/SryAKR/J embryos, characterised by gonadal poles (brackets) lacking markers of testis development and expressing markers of ovary development

reproductive system
small testis ( J:153050 )
• at 11 weeks
primary sex reversal ( J:153050 )
• in XY gonads

endocrine/exocrine glands
small testis ( J:153050 )
• at 11 weeks




Genotype
MGI:5461495
cx5
Allelic
Composition		 Gadd45gtm1Jni/Gadd45g+
Map3k4tm1Flv/Map3k4+
Genetic
Background		 involves: 129P2/OlaHsd * 129S6/SvEvTac * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gadd45gtm1Jni mutation (0 available); any Gadd45g mutation (11 available)
Map3k4tm1Flv mutation (1 available); any Map3k4 mutation (79 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
endocrine/exocrine glands
abnormal testis development ( J:191096 )
• significant numbers of Stra8-positive meiotic germ cells are detectable at the poles of XY gonads at E14.5 indicating a activation of ovarian pathways

reproductive system
abnormal testis development ( J:191096 )
• significant numbers of Stra8-positive meiotic germ cells are detectable at the poles of XY gonads at E14.5 indicating a activation of ovarian pathways




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Send questions and comments to User Support. 		last database update
09/30/2025
MGI 6.24 		The Jackson Laboratory