All Phenotypes Tg(ACTB-HSF1)1Anak MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Tg(ACTB-HSF1)1Anak
transgene insertion 1, Akira Nakai
MGI:3044263

Summary

2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
cx1	Hsf1^tm1Anak/Hsf1^tm1Anak Tg(ACTB-HSF1)1Anak/?	involves: C57BL/6 * CBA * ICR	MGI:3044360
tg2	Tg(ACTB-HSF1)1Anak/?	involves: C57BL/6 * CBA	MGI:3044363

Allelic Composition	Hsf1^tm1Anak/Hsf1^tm1Anak Tg(ACTB-HSF1)1Anak/?
Genetic Background	involves: C57BL/6 * CBA * ICR

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Hsf1^tm1Anak mutation (1 available); any Hsf1 mutation (25 available)
Tg(ACTB-HSF1)1Anak mutation (0 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

endocrine/exocrine glands

abnormal seminiferous tubule morphology ( J:89846 )

• diameter of seminiferous tubules is larger than in mice expressing endogenous Hsf1 as well as the transgene

decreased testis weight ( J:89846 )

• testis weight is low compared to normal controls but greater than in mice expressing endogenous Hsf1 as well as the transgene

reproductive system

reproductive system phenotype ( J:89846 )

N	• spermatogenesis is normal

abnormal seminiferous tubule morphology ( J:89846 )

• diameter of seminiferous tubules is larger than in mice expressing endogenous Hsf1 as well as the transgene

decreased testis weight ( J:89846 )

• testis weight is low compared to normal controls but greater than in mice expressing endogenous Hsf1 as well as the transgene

Allelic Composition	Tg(ACTB-HSF1)1Anak/?
Genetic Background	involves: C57BL/6 * CBA

Find Mice

Using the International Mouse Strain Resource (IMSR)
No mouse lines available in IMSR.
See publication links below for author information.

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

reproductive system

arrest of male meiosis ( J:61442 )

• spermatogenesis arrested at pachytene stage

• apoptosis in seminiferous tubules was common

abnormal male reproductive system morphology ( J:61442 )

small seminiferous tubules ( J:61442 )

• diameter of seminiferous tubules reduced about 20-30%

decreased testis weight ( J:61442 )

• testis weight about 42% of control weight

male infertility ( J:61442 )

• only males are infertile