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Targeted Allele Detail
Symbol: Hsf1tm1Anak
Name: heat shock factor 1; targeted mutation 1, Akira Nakai
MGI ID: MGI:3044161
Gene: Hsf1  Location: Chr15:76361562-76385355 bp, + strand  Genetic Position: Chr15, 35.95 cM
Alliance: Hsf1tm1Anak page
Germline Transmission:  Earliest citation of germline transmission: J:90551
Parent Cell Line:  TT2 (ES Cell)
Strain of Origin:  (C57BL/6NCrlj x CBA/JNCrlj)F1
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
Mutation detailsExons 2-4 were replaced with a neo cassette. Exons 2 and 3 encode the DNA-binding domain. Southern blot confirmed recombination. (J:89846)
View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Hsf1 Mutation:  15 strains or lines available
Original:  J:90551 Inouye S, et al., Activation of heat shock genes is not necessary for protection by heat shock transcription factor 1 against cell death due to a single exposure to high temperatures. Mol Cell Biol. 2003 Aug;23(16):5882-95
All:  31 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
MGI 6.22
The Jackson Laboratory