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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Hsf1tm1Anak
targeted mutation 1, Akira Nakai
MGI:3044161
Summary 4 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
Hsf1tm1Anak/Hsf1tm1Anak involves: C57BL/6 * CBA * ICR MGI:3044359
hm2
Hsf1tm1Anak/Hsf1tm1Anak involves: ICR MGI:3057291
cx3
Hsf1tm1Anak/Hsf1tm1Anak
Tg(ACTB-HSF1)1Anak/?
involves: C57BL/6 * CBA * ICR MGI:3044360
cx4
Hsf1tm1Anak/Hsf1tm1Anak
Hsf4tm1Anak/Hsf4tm1Anak
involves: C57BL/6 * CBA * ICR MGI:3057290


Genotype
MGI:3044359
hm1
Allelic
Composition
Hsf1tm1Anak/Hsf1tm1Anak
Genetic
Background
involves: C57BL/6 * CBA * ICR
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Hsf1tm1Anak mutation (1 available); any Hsf1 mutation (15 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
reproductive system
N
• homozygous males are fertile with testes of normal weight and histologically normal as well
• apoptosis in seminiferous tubules of heat shocked testes was considerably reduced as compared to controls
• few late pachytene spermatocytes die as a result of heat stress




Genotype
MGI:3057291
hm2
Allelic
Composition
Hsf1tm1Anak/Hsf1tm1Anak
Genetic
Background
involves: ICR
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Hsf1tm1Anak mutation (1 available); any Hsf1 mutation (15 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
vision/eye
N
• no cataracts are seen and lens epithelial cell morphology is normal




Genotype
MGI:3044360
cx3
Allelic
Composition
Hsf1tm1Anak/Hsf1tm1Anak
Tg(ACTB-HSF1)1Anak/?
Genetic
Background
involves: C57BL/6 * CBA * ICR
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Hsf1tm1Anak mutation (1 available); any Hsf1 mutation (15 available)
Tg(ACTB-HSF1)1Anak mutation (0 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
endocrine/exocrine glands
• diameter of seminiferous tubules is larger than in mice expressing endogenous Hsf1 as well as the transgene
• testis weight is low compared to normal controls but greater than in mice expressing endogenous Hsf1 as well as the transgene

reproductive system
N
• spermatogenesis is normal
• diameter of seminiferous tubules is larger than in mice expressing endogenous Hsf1 as well as the transgene
• testis weight is low compared to normal controls but greater than in mice expressing endogenous Hsf1 as well as the transgene




Genotype
MGI:3057290
cx4
Allelic
Composition
Hsf1tm1Anak/Hsf1tm1Anak
Hsf4tm1Anak/Hsf4tm1Anak
Genetic
Background
involves: C57BL/6 * CBA * ICR
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Hsf1tm1Anak mutation (1 available); any Hsf1 mutation (15 available)
Hsf4tm1Anak mutation (1 available); any Hsf4 mutation (24 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
vision/eye
• the lens capsule is always ruptured; however, lens epithelial cell proliferation and morphology are fairly normal unlike in Hsf4tm1Anak homozygotes
• more severe cataracts are seen compared to Hsf4tm1Anak homozygotes





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last database update
01/24/2023
MGI 6.22
The Jackson Laboratory