Phenotypes associated with this allele

• Allele Symbol: Tg(SERPINA1-IGHG1/Il1rl1)423Zbz
• Allele Name: transgene insertion 423, University Hospital, Zurich
• Allele ID: MGI:3044038
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
tg1	Tg(SERPINA1-IGHG1/Il1rl1)423Zbz/?	involves: C3H * C57BL/6	MGI:3718679

Genotype
MGI:3718679

tg1

• Allelic Composition: Tg(SERPINA1-IGHG1/Il1rl1)423Zbz/?
• Genetic Background: involves: C3H * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

hematopoietic system

increased eosinophil cell number ( J:63507 )

• following infection with N. brasiliensis, eosinophil numbers in peripheral blood increase to 12 to 15% of total blood cells

abnormal eosinophil physiology ( J:63507 )

• at day 12 following infection with N. brasiliensis, eosinophil recruitment into the llungs is decreased by 2-fold compared to wild-type mice

immune system

increased eosinophil cell number ( J:63507 )

• following infection with N. brasiliensis, eosinophil numbers in peripheral blood increase to 12 to 15% of total blood cells

abnormal eosinophil physiology ( J:63507 )

• at day 12 following infection with N. brasiliensis, eosinophil recruitment into the llungs is decreased by 2-fold compared to wild-type mice

decreased interleukin-5 secretion ( J:63507 )

• following infection with N. brasiliensis, IL-5 production is decreased

abnormal response to infection ( J:63507 )

• 9 days following infection with N. brasiliensis, IL-5+ CD4 T cells are slightly decreased and IL-5 production is decreased

• following infection with N. brasiliensis, eosinophil numbers in peripheral blood increase to 12 to 15% of total blood cells

• at day 12 following infection with N. brasiliensis, eosinophil recruitment into the lungs is decreased by 2-fold compared to wild-type mice

• however, the number of parasitic eggs following infection is equivalent to in wild-type mice