Analysis Tools
mortality/aging
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• approximately 50% of embryos had died by E10.5 and none were observed at E11.5
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cardiovascular system
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• discontinuities of the vascular wall and reduction of pericytes and smooth muscle cells observed in the aorta
• the endothelial cells lining the major vessels appeared ultrastructurally normal
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• while the primary vasculature was established in embryos, it failed to remodel to the structured pattern of the wild-type vasculature
• progressive disorganization, characterized by excessive fusion and abnormal patterning
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• impaired angiogenesis of the yolk sac resulting in a primitive vascular plexus lacking vitellint blood vessles
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• by E9.5, ~40% of embryos exhibited significantly enlarged pericardial sacs
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embryo
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• impaired angiogenesis of the yolk sac resulting in a primitive vascular plexus lacking vitellint blood vessles
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growth/size/body
