Phenotypes associated with this allele

• Allele Symbol: Tg(Nefh-cre)12Kul
• Allele Name: transgene insertion 12, Ashok B Kulkarni
• Allele ID: MGI:3043822
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
cn1	Cdk5^tm2Kul/Cdk5^tm2Kul Tg(Nefh-cre)12Kul/0	involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * FVB/N	MGI:3043832

Genotype
MGI:3043832

cn1

• Allelic Composition: Cdk5^tm2Kul/Cdk5^tm2Kul; Tg(Nefh-cre)12Kul/0
• Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * FVB/N

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

nervous system

abnormal brain development ( J:89561 )

• 25% exhibited neuronal migration defects in the cerebral cortex; restricted to later-generated cortical neurons

• immunostaining of ectopic neurons indicated that the defects were cell-autonomous

abnormal hippocampus development ( J:89561 )

• disorganization of the CA3 region

• the CA1 region was unaffected

abnormal cerebellum development ( J:89561 )

• many granule cells were arrested in the molecular layer

• in some cases, defects in Purkinje cell migration were observed

abnormal olfactory bulb development ( J:89561 )

• disorganized mitral cell layer

• reduced granule cell density relative to controls