Tg(Nefh-cre)12Kul
Transgene Detail

Summary

• Symbol: Tg(Nefh-cre)12Kul
• Name: transgene insertion 12, Ashok B Kulkarni
• MGI ID: MGI:3043822
• Synonyms: Tg mNF-H-cre 12
• Transgene: Tg(Nefh-cre)12Kul Location: unknown
• Alliance: Tg(Nefh-cre)12Kul page

Transgene origin

• Strain of Origin: FVB/N

Transgene description

• Transgene Type: Transgenic (Recombinase)
• Mutation: Insertion
• Tg(Nefh-cre)12Kul expression driven by 1 gene
  Transgene expression driven by:
  

  Organism	Driver Gene	Note
  mouse	Nefh (MGI:97309)

• Mutation details: An 8.5 kb promoter fragment of mouse Nefh, containing the 5' UTR and 40 bp of non-coding sequence of exon 1 ending before the start codon, was adjoined to sequence encoding cre recombinase with an SV40 nuclear localization signal. An SV40 polyadenylation signal was also included in the construct. Expression of cre recombinase is driven in neurons of the brain and spinal cord during late development (around E18.5). Line 12 is best described and is representative of the other lines. (J:82025)

Recombinase activity

Activity:	Tissue activity of this recombinase allele
Driver:	Nefh (mouse) Summary of all recombinase alleles driven by Nefh. Comparative matrix view of recombinase activities Alliance mouse Nefh gene page

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 3 strains available Cell Lines: 0 lines available

References

• Original: J:82025 Hirasawa M, et al., Neuron-specific expression of Cre recombinase during the late phase of brain development. Neurosci Res. 2001 Jun;40(2):125-32
• All: 15 reference(s)