Phenotypes associated with this allele
Allelic Composition |
Lrp6Gw/Lrp6Gw
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Genetic Background |
involves: 101/H * BALB/c * C3H/HeH |
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Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Lrp6Gw mutation
(0 available);
any
Lrp6 mutation
(95 available)
|
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nervous system
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• at E9.5 and E10.5, 39% of mice exhibit reduced forebrain size compared with wild-type mice
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• mice exhibit reduced rostral and dorsal telencephalon size compared with wild-type mice
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limbs/digits/tail
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• 86% of mice exhibit bent tails unlike wild-type mice
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growth/size/body
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• 30-39% of mice exhibit head malformations compared with wild-type mice
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Allelic Composition |
Lrp6Gw/Lrp6Gw
|
|
Genetic Background |
involves: 101/H * BALB/cOlaHsd * C3H/HeH |
|
Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Lrp6Gw mutation
(0 available);
any
Lrp6 mutation
(95 available)
|
|
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embryo
growth/size/body
nervous system
|
• forebrain defect at E9.5
|
Allelic Composition |
Lrp6Gw/Lrp6+
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|
Genetic Background |
involves: 101/H * BALB/c * C3H/HeH |
|
Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Lrp6Gw mutation
(0 available);
any
Lrp6 mutation
(95 available)
|
|
|
limbs/digits/tail
|
• in more than half of mice
• 68% of mice exhibit bent tails unlike wild-type mice
|
nervous system
growth/size/body
Allelic Composition |
Lrp6Gw/Lrp6+
|
|
Genetic Background |
involves: 101/H * BALB/cOlaHsd * C3H/HeH |
|
Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Lrp6Gw mutation
(0 available);
any
Lrp6 mutation
(95 available)
|
|
|
Allelic Composition |
Ctnnb1Bfc/Ctnnb1+ Dkk1tm1Lmgd/Dkk1+ Lrp6Gw/Lrp6+
|
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Genetic Background |
either: (involves: 101/H * 129 * BALB/cCrl * C3H) or (involves: 101/H * 129 * BALB/cCrl * C3H * C57BL/6) |
|
Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ctnnb1Bfc mutation
(4 available);
any
Ctnnb1 mutation
(49 available)
Dkk1tm1Lmgd mutation
(0 available);
any
Dkk1 mutation
(17 available)
Lrp6Gw mutation
(0 available);
any
Lrp6 mutation
(95 available)
|
|
|
embryo
|
• 23% of mice exhibit complete head truncation unlike wild-type mice
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growth/size/body
|
• all mice exhibit head reduction defects unlike wild-type mice
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Allelic Composition |
Ctnnb1Bfc/Ctnnb1+ Lrp6Gw/Lrp6+
|
|
Genetic Background |
either: (involves: 101/H * BALB/cCrl * C3H) or (involves: 101/H * BALB/cCrl * C3H * C57BL/6) |
|
Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ctnnb1Bfc mutation
(4 available);
any
Ctnnb1 mutation
(49 available)
Lrp6Gw mutation
(0 available);
any
Lrp6 mutation
(95 available)
|
|
|
growth/size/body
|
• 86% of mice exhibit head reduction defects unlike wild-type mice
|
Allelic Composition |
Dkk1tm1Lmgd/Dkk1+ Lrp6Gw/Lrp6+
|
|
Genetic Background |
involves: 101/H * 129 * BALB/c * C3H |
|
Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Dkk1tm1Lmgd mutation
(0 available);
any
Dkk1 mutation
(17 available)
Lrp6Gw mutation
(0 available);
any
Lrp6 mutation
(95 available)
|
|
|
limbs/digits/tail
growth/size/body
|
Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Dkk1tm1Lmgd mutation
(0 available);
any
Dkk1 mutation
(17 available)
Lrp6Gw mutation
(0 available);
any
Lrp6 mutation
(95 available)
|
|
|
Allelic Composition |
Lrp6Gw/Lrp6+ Wnt3tm1Brd/Wnt3+
|
|
Genetic Background |
involves: 101/H * 129S7/SvEvBrd * BALB/c * C3H |
|
Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Lrp6Gw mutation
(0 available);
any
Lrp6 mutation
(95 available)
Wnt3tm1Brd mutation
(0 available);
any
Wnt3 mutation
(25 available)
|
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