Analysis Tools
cardiovascular system
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• severely reduced outflow tract cushions, which developed into a shortened outflow tract
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Allele Symbol Allele Name Allele ID |
Bmp4tm1.1Jfm targeted mutation 1.1, James F Martin MGI:3042751 |
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| Summary |
2 genotypes
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• severely reduced outflow tract cushions, which developed into a shortened outflow tract
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• most mice died by E13.5, although an occasional fetus survived to E18.5, putatively due to variability in the expression of cre recombinase
• peripheral edema that was often associated with pericardial effusion indicated that lethality was secondary to heart failure
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• severe defects in the architecture of the brancial arch artery due to impaired remodeling
• variable branching and abnormal regression and remodeling
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• only one pulmonary artery originates from the ductus arteriosis and the fate of the second pulmonary artery is not clear
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• majority exhibited a proximal aortopulmonary window, in which the proximal aspect of the outflow tract septum failed to form
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• the left carotid artery branched either from the right brachiocephalic artery in the most severely affected embryos or directly from the aorta in more mildly affected embryos
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• interruption (type B) of the aorta between the left carotid and the left subclavian arteries
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• growth was delayed and the cushions were hypoplastic
• cell proliferation is reduced in the cushion mesenchyme, relative to wild-type
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• observed in all examined fetuses
• putatively due to a defect in the conotruncal mesenchyme
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• hypoplastic semilunar valves
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• peripheral edema that was often associated with pericardial effusion
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• peripheral edema that was often associated with pericardial effusion
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• peripheral edema that was often associated with pericardial effusion
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• severe defects in the architecture of the brancial arch artery due to impaired remodeling
• variable branching and abnormal regression and remodeling
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• severe defects in the architecture of the brancial arch artery due to impaired remodeling
• variable branching and abnormal regression and remodeling
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 05/07/2024 MGI 6.23 |
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