Phenotypes associated with this allele

• Allele Symbol: Arnt^tm1Bra
• Allele Name: targeted mutation 1, Christopher A Bradfield
• Allele ID: MGI:3042111
• Summary: 4 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Arnt^tm1Bra/Arnt^tm1Bra	B6.129-Arnt^tm1Bra	MGI:3042112
hm2	Arnt^tm1Bra/Arnt^tm1Bra	involves: 129	MGI:3521906
cn3	Arnt^tm1Bra/Arnt^tm1Bra Hprt1^tm1(Pck1-cre)Vhh/Y Vhl^tm1Jae/Vhl^tm1Jae	involves: 129 * BALB/c * C57BL/6	MGI:3621462
cn4	Arnt^tm1Bra/Arnt^tm1Bra Vhl^tm1Jae/Vhl^tm1Jae Speer6-ps1^Tg(Alb-cre)21Mgn/Speer6-ps1^+	involves: 129 * BALB/c * C57BL/6 * DBA	MGI:3621473

Genotype
MGI:3042112

hm1

• Allelic Composition: Arnt^tm1Bra/Arnt^tm1Bra
• Genetic Background: B6.129-Arnt^tm1Bra

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

prenatal lethality, incomplete penetrance ( J:89470 )

• partial embryonic lethality is seen

homeostasis/metabolism

decreased physiological sensitivity to xenobiotic ( J:89470 )

• homozygous mice are resistant to TCDD induced hepatotoxicity and thymic involution

• however, induction of Cyp1a1 and Cyp1a2 ethoxyresorufin O-deethylase activity is not impaired

reproductive system

female infertility ( J:89470 )

♀ • homozygous females are unable to maintain pregnancy

♀ • homozygous males are fertile

Genotype
MGI:3521906

hm2

• Allelic Composition: Arnt^tm1Bra/Arnt^tm1Bra
• Genetic Background: involves: 129

cardiovascular system

patent ductus venosus ( J:94465 )

• a patent ductus venosus (shunting blood around the liver) was seen in 11/12 mutants

• exposure to non-teratogenic concentration of dioxin on E16.5 resulted in closure of the ductus venosus in all mutants

cellular

patent ductus venosus ( J:94465 )

• a patent ductus venosus (shunting blood around the liver) was seen in 11/12 mutants

• exposure to non-teratogenic concentration of dioxin on E16.5 resulted in closure of the ductus venosus in all mutants

Genotype
MGI:3621462

cn3

• Allelic Composition: Arnt^tm1Bra/Arnt^tm1Bra; Hprt1^{tm1(Pck1-cre)Vhh}/Y; Vhl^tm1Jae/Vhl^tm1Jae
• Genetic Background: involves: 129 * BALB/c * C57BL/6

renal/urinary system

renal/urinary system phenotype ( J:106705 )

♂N • no macroscopic or microscopic renal cysts are detected

liver/biliary system

hepatic steatosis ( J:97652 )

♂ • moderate steatosis without angiectasia or endothelial cell proliferation is seen only in mutants over 9 months of age

neoplasm

neoplasm ( J:97652 )

♂N • no hepatic hemangiomas are seen

hematopoietic system

hematopoietic system phenotype ( J:97652 )

♂N • red cell count and hemoglobin levels are similar to controls

Genotype
MGI:3621473

cn4

• Allelic Composition: Arnt^tm1Bra/Arnt^tm1Bra; Vhl^tm1Jae/Vhl^tm1Jae; Speer6-ps1^{Tg(Alb-cre)21Mgn}/Speer6-ps1⁺
• Genetic Background: involves: 129 * BALB/c * C57BL/6 * DBA

liver/biliary system

liver/biliary system phenotype ( J:97652 )

N • livers appear histologically normal at 4 - 6 weeks of age