All Phenotypes Arnt<tm1Bra> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Arnt^tm1Bra
targeted mutation 1, Christopher A Bradfield
MGI:3042111

Summary

4 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Arnt^tm1Bra/Arnt^tm1Bra	B6.129-Arnt^tm1Bra	MGI:3042112
hm2	Arnt^tm1Bra/Arnt^tm1Bra	involves: 129	MGI:3521906
cn3	Arnt^tm1Bra/Arnt^tm1Bra Hprt1^{tm1(Pck1-cre)Vhh}/Y Vhl^tm1Jae/Vhl^tm1Jae	involves: 129 * BALB/c * C57BL/6	MGI:3621462
cn4	Arnt^tm1Bra/Arnt^tm1Bra Vhl^tm1Jae/Vhl^tm1Jae Speer6-ps1^{Tg(Alb-cre)21Mgn}/Speer6-ps1⁺	involves: 129 * BALB/c * C57BL/6 * DBA	MGI:3621473

Allelic Composition	Arnt^tm1Bra/Arnt^tm1Bra
Genetic Background	B6.129-Arnt^tm1Bra

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Arnt^tm1Bra mutation (0 available); any Arnt mutation (62 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

prenatal lethality, incomplete penetrance ( J:89470 )

• partial embryonic lethality is seen

homeostasis/metabolism

decreased physiological sensitivity to xenobiotic ( J:89470 )

• homozygous mice are resistant to TCDD induced hepatotoxicity and thymic involution

• however, induction of Cyp1a1 and Cyp1a2 ethoxyresorufin O-deethylase activity is not impaired

reproductive system

female infertility ( J:89470 )

• homozygous females are unable to maintain pregnancy

• homozygous males are fertile

Allelic Composition	Arnt^tm1Bra/Arnt^tm1Bra
Genetic Background	involves: 129

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Arnt^tm1Bra mutation (0 available); any Arnt mutation (62 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

cardiovascular system

patent ductus venosus ( J:94465 )

• a patent ductus venosus (shunting blood around the liver) was seen in 11/12 mutants

• exposure to non-teratogenic concentration of dioxin on E16.5 resulted in closure of the ductus venosus in all mutants

cellular

patent ductus venosus ( J:94465 )

• a patent ductus venosus (shunting blood around the liver) was seen in 11/12 mutants

• exposure to non-teratogenic concentration of dioxin on E16.5 resulted in closure of the ductus venosus in all mutants

Allelic Composition	Arnt^tm1Bra/Arnt^tm1Bra Hprt1^{tm1(Pck1-cre)Vhh}/Y Vhl^tm1Jae/Vhl^tm1Jae
Genetic Background	involves: 129 * BALB/c * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Arnt^tm1Bra mutation (0 available); any Arnt mutation (62 available)
Hprt1^{tm1(Pck1-cre)Vhh} mutation (0 available); any Hprt1 mutation (1274 available)
Vhl^tm1Jae mutation (2 available); any Vhl mutation (16 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

renal/urinary system

renal/urinary system phenotype ( J:106705 )

N	• no macroscopic or microscopic renal cysts are detected

liver/biliary system

hepatic steatosis ( J:97652 )

• moderate steatosis without angiectasia or endothelial cell proliferation is seen only in mutants over 9 months of age

neoplasm

neoplasm ( J:97652 )

N	• no hepatic hemangiomas are seen

hematopoietic system

hematopoietic system phenotype ( J:97652 )

N	• red cell count and hemoglobin levels are similar to controls

Allelic Composition	Arnt^tm1Bra/Arnt^tm1Bra Vhl^tm1Jae/Vhl^tm1Jae Speer6-ps1^{Tg(Alb-cre)21Mgn}/Speer6-ps1⁺
Genetic Background	involves: 129 * BALB/c * C57BL/6 * DBA

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Arnt^tm1Bra mutation (0 available); any Arnt mutation (62 available)
Speer6-ps1^{Tg(Alb-cre)21Mgn} mutation (6 available); any Speer6-ps1 mutation (4 available)
Vhl^tm1Jae mutation (2 available); any Vhl mutation (16 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

liver/biliary system

liver/biliary system phenotype ( J:97652 )

N	• livers appear histologically normal at 4 - 6 weeks of age

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