All Phenotypes Tlr7<tm1Flv> MGI Mouse

Phenotypes associated with this allele

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Tlr7^tm1Flv/Tlr7^tm1Flv	B6.129S1-Tlr7^tm1Flv	MGI:4837537
hm2	Tlr7^tm1Flv/Tlr7^tm1Flv	involves: 129S1/Sv	MGI:3042846
cx3	Fcgr2b^tm1Ttk/Fcgr2b^tm1Ttk Tlr7^tm1Flv/Y X/Yaa	B6.Cg-Fcgr2b^tm1Ttk Tlr7^tm1Flv Yaa	MGI:5488508
cx4	Tlr7^tm1Flv/Y X/Yaa	B6.Cg-Tlr7^tm1Flv Yaa	MGI:5488500
cx5	Fas^lpr/Fas^lpr Tlr7^tm1Flv/Y	involves: 129S1/Sv * C57BL/6 * MRL/Mp	MGI:5478501
ot6	Tlr7^tm1Flv/Y	B6.129S1-Tlr7^tm1Flv	MGI:5488507

Allelic Composition	Tlr7^tm1Flv/Tlr7^tm1Flv
Genetic Background	B6.129S1-Tlr7^tm1Flv

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tlr7^tm1Flv mutation (1 available); any Tlr7 mutation (21 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

decreased IgG level ( J:165267 )

• in the serum and as glomerular deposition

decreased IgG1 level ( J:165267 )

decreased IgG2a level ( J:165267 )

decreased IgM level ( J:165267 )

• in the serum and as glomerular deposition

decreased anti-insulin autoantibody level ( J:165267 )

hematopoietic system

decreased IgG level ( J:165267 )

• in the serum and as glomerular deposition

decreased IgG1 level ( J:165267 )

decreased IgG2a level ( J:165267 )

decreased IgM level ( J:165267 )

• in the serum and as glomerular deposition

Allelic Composition	Tlr7^tm1Flv/Tlr7^tm1Flv
Genetic Background	involves: 129S1/Sv

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tlr7^tm1Flv mutation (1 available); any Tlr7 mutation (21 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

decreased circulating interferon-alpha level ( J:89257 )

• while IFNalpha secretion in response to infection with vesicular stomatitis virus (a ssRNA virus) was similar to controls, serum levels of IFNalpha were reduced after infection relative to controls

homeostasis/metabolism

decreased circulating interferon-alpha level ( J:89257 )

Allelic Composition	Fcgr2b^tm1Ttk/Fcgr2b^tm1Ttk Tlr7^tm1Flv/Y X/Yaa
Genetic Background	B6.Cg-Fcgr2b^tm1Ttk Tlr7^tm1Flv Yaa

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Fcgr2b^tm1Ttk mutation (7 available); any Fcgr2b mutation (49 available)
Tlr7^tm1Flv mutation (1 available); any Tlr7 mutation (21 available)
Yaa mutation (18 available); any Yaa mutation (21 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

premature death ( J:127600 )

• survival is prolonged compared to mutant mice wild-type for Tlr7

immune system

enlarged spleen ( J:127600 )

• less severe at 5 months of age compared to mutant mice wild-type for Tlr7

abnormal splenocyte physiology ( J:127600 )

• activation of splenocytes is reduced compared to mutant mice wild-type for Tlr7

autoimmune response ( J:127600 )

• autoantibodies show a homogeneous nuclear pattern

increased susceptibility to systemic lupus erythematosus ( J:127600 )

• develop a lupus like syndrome at a later age and in lower numbers compared to mutant mice wild-type for Tlr7

increased anti-nuclear antigen antibody level ( J:127600 )

• increase in anti-RNA IgG levels in the serum at 4 - 6 months of age is less severe than in mutant mice wild-type for Tlr7 and is similar to mice homozygous for Fcgr2b^tm1Ttk alone

renal/urinary system

abnormal kidney morphology ( J:127600 )

• kidney disease is less severe at 5 months of age compared to mutant mice wild-type for Tlr7

hematopoietic system

enlarged spleen ( J:127600 )

• less severe at 5 months of age compared to mutant mice wild-type for Tlr7

abnormal splenocyte physiology ( J:127600 )

• activation of splenocytes is reduced compared to mutant mice wild-type for Tlr7

growth/size/body

enlarged spleen ( J:127600 )

• less severe at 5 months of age compared to mutant mice wild-type for Tlr7

Allelic Composition	Tlr7^tm1Flv/Y X/Yaa
Genetic Background	B6.Cg-Tlr7^tm1Flv Yaa

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tlr7^tm1Flv mutation (1 available); any Tlr7 mutation (21 available)
Yaa mutation (18 available); any Yaa mutation (21 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

hematopoietic system

hematopoietic system phenotype ( J:127600 )

N	• spleen marginal zone B cell numbers are similar to wild-type controls • splenocyte proliferation in response to imiquimod is similar to controls

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
NOT	systemic lupus erythematosus	DOID:9074	OMIM:152700 OMIM:300809 OMIM:605480 OMIM:608437 OMIM:609903 OMIM:609939 OMIM:610065 OMIM:610066 OMIM:612254 OMIM:612378 OMIM:613145 OMIM:614420	J:127600

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

decreased double-negative T cell number ( J:113557 )

• decrease in accumulation of double-negative T cells in the spleen compared to Fas^lpr homozygotes

abnormal CD4-positive, alpha beta T cell morphology ( J:113557 )

• decrease in proportion of CD4+ T cells expressing CD44, both in the lymph node and spleen compared to Fas^lpr homozygotes

decreased spleen weight ( J:113557 )

• spleen weight is decreased compared to Fas^lpr homozygotes

abnormal B cell activation ( J:113557 )

• general B cell activation is inhibited compared to Fas^lpr homozygotes, as indicated by decreased CD44 expression in splenic B cells

decreased IgG2a level ( J:113557 )

• serum IgG2a levels are decreased compared to Fas^lpr homozygotes

decreased IgG3 level ( J:113557 )

• serum IgG3 levels are decreased compared to Fas^lpr homozygotes

abnormal lymph node size ( J:113557 )

• lymph node weight is decreased compared to Fas^lpr homozygotes

abnormal plasmacytoid dendritic cell physiology ( J:113557 )

• plasmacytoid DCs exhibit a more immature phenotype compared to Fas^lpr homozygotes, with decreased expression of MHC class II

decreased susceptibility to systemic lupus erythematosus ( J:113557 )

• renal disease is significantly decreased compared to Fas^lpr homozygotes, with mice showing decreased glomerular protein deposition and preserved glomerular structure

• although skin disease is evident in mutants, it occurs with a very low frequency and very little is seen at 16 weeks of age

decreased autoantibody level ( J:113557 )

• mutants exhibit impaired generation of antibodies to RNA complexes and generation of high-titer Smith antibodies is blocked

increased autoantibody level ( J:113557 )

• DNA autoantibodies are seen in mutants

increased anti-chromatin antibody level ( J:113557 )

hematopoietic system

decreased double-negative T cell number ( J:113557 )

• decrease in accumulation of double-negative T cells in the spleen compared to Fas^lpr homozygotes

abnormal CD4-positive, alpha beta T cell morphology ( J:113557 )

• decrease in proportion of CD4+ T cells expressing CD44, both in the lymph node and spleen compared to Fas^lpr homozygotes

decreased spleen weight ( J:113557 )

• spleen weight is decreased compared to Fas^lpr homozygotes

abnormal B cell activation ( J:113557 )

• general B cell activation is inhibited compared to Fas^lpr homozygotes, as indicated by decreased CD44 expression in splenic B cells

decreased IgG2a level ( J:113557 )

• serum IgG2a levels are decreased compared to Fas^lpr homozygotes

decreased IgG3 level ( J:113557 )

• serum IgG3 levels are decreased compared to Fas^lpr homozygotes

Allelic Composition	Tlr7^tm1Flv/Y
Genetic Background	B6.129S1-Tlr7^tm1Flv

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tlr7^tm1Flv mutation (1 available); any Tlr7 mutation (21 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

decreased splenocyte proliferation ( J:127600 )

• absence of the splenocyte proliferation response to imiquimod

increased marginal zone B cell number ( J:127600 )

• slight increase

hematopoietic system

decreased splenocyte proliferation ( J:127600 )

• absence of the splenocyte proliferation response to imiquimod

increased marginal zone B cell number ( J:127600 )

• slight increase

cellular

decreased splenocyte proliferation ( J:127600 )

• absence of the splenocyte proliferation response to imiquimod

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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