Phenotypes associated with this allele

• Allele Symbol: Tg(Mt1-Tgfa)149Bri
• Allele Name: transgene insertion 149, Ralph L Brinster
• Allele ID: MGI:3040606
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
cx1	Kcmf1^Gt(XE080)Byg/Kcmf1^Gt(XE080)Byg Tg(Mt1-Tgfa)149Bri/0	involves: 129P2/OlaHsd * C57BL/6 * C57BL/6J * SJL	MGI:4818401
tg2	Tg(Mt1-Tgfa)149Bri/0	involves: C57BL/6 * SJL	MGI:4818402

Genotype
MGI:4818401

cx1

• Allelic Composition: Kcmf1^Gt(XE080)Byg/Kcmf1^Gt(XE080)Byg; Tg(Mt1-Tgfa)149Bri/0
• Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * C57BL/6J * SJL

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

endocrine/exocrine glands

abnormal pancreas morphology ( J:162125 )

• at 6 and 12 months, mice exhibit reduced number and size of tubular complexes compared with Tg(Mt1-Tgfa)149Bri mice

decreased pancreas weight ( J:162125 )

• compared with Tg(Mt1-Tgfa)149Bri mice

abnormal pancreas physiology ( J:162125 )

• proliferation of pancreatic ductal cells is reduced compared to in Tg(Mt1-Tgfa)149Bri mice

neoplasm

decreased tumor incidence ( J:162125 )

• unlike Tg(Mt1-Tgfa)149Bri mice, no malignant transformation are observed in the pancreas

Genotype
MGI:4818402

tg2

• Allelic Composition: Tg(Mt1-Tgfa)149Bri/0
• Genetic Background: involves: C57BL/6 * SJL

neoplasm

increased pancreatic intraepithelial neoplasia incidence ( J:162125 )

endocrine/exocrine glands

increased pancreatic intraepithelial neoplasia incidence ( J:162125 )